N-Hydroxy-1,8-naphthalimide TCI H1040

Chemical Identity

CAS No.: 7797-81-1
PubChem: CID 82263·SID 87571387
Formula: C12H7NO3
Molecular weight: 213.19 g/mol
Purity: >97.0%(HPLC)(T)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-hydroxybenzo[de]isoquinoline-1,3-dione
SMILES: C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)O
InChIKey: KTWCUGUUDHJVIH-UHFFFAOYSA-N

Rp 980.700,00

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N-Hydroxy-1,8-naphthalimide (NHN) is a chemical compound widely used as a building block in the synthesis of heterocyclic compounds and complex organic molecules. Its stable structure makes it a versatile reagent in various chemical reactions, including acylation and substitution reactions. In the laboratory, NHN plays a crucial role in constructing more intricate molecular frameworks, especially in organic chemistry and pharmacological synthesis. It is valued for its ability to participate in controlled chemical transformations, making it an essential tool for researchers aiming to develop new compounds with specific functionalities.

The chemical properties of N-Hydroxy-1,8-naphthalimide make it a preferred choice for laboratory use. It exhibits excellent reactivity while maintaining stability under typical laboratory conditions, which simplifies handling and storage. Its ability to interact with a variety of functional groups allows it to be used in a wide range of synthetic pathways. Additionally, its resistance to degradation ensures consistent performance in experiments, contributing to reliable and reproducible results.

In Indonesian laboratories, N-Hydroxy-1,8-naphthalimide is extensively used in chemical research, particularly in higher education institutions and research organizations. It is a key component in the development of new compounds, especially in pharmaceutical and organic chemistry studies. Its reliability and stability make it a go-to material for researchers seeking a dependable building block for complex molecular synthesis.

Advantages (TCI brochure)

RAE reduction potential shown in comparison chart

TCI brochures (PDF)

N-Hydroxyphthalimide Derivatives for the Synthesis of Redox Active Esters 2024-02-06 · p. 1

Related TCI products

Organic synthesis applications benefit from NHN’s ability to participate in acylation and substitution reactions, enabling the construction of complex molecular structures.
Pharmacological research uses NHN as a building block for developing new drug compounds due to its reactivity and stability.
Chemical education in Indonesian universities incorporates NHN in teaching practical synthesis techniques to students.
Industrial research laboratories rely on NHN for its consistent performance in controlled chemical transformations.
Analytical chemistry applications utilize NHN as a reference compound for testing and validating synthetic processes.

Brand	TCI
CAS number	7797-81-1
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	Available in various quantities as per standard laboratory supply
Physical form	Solid
Storage	Store in a cool, dry place away from direct sunlight

Data from the TCI brochure

Ep (vs. Fc+/Fc) of RAE	-1.589 V (RAE with R = phenylcyclopropyl group as drawn in brochure)

Source: TCI brochure RR190 (2024-02-06)

N-Hydroxy-1,8-naphthalimide should be stored in a cool, dry environment to maintain its stability and prevent degradation. It is recommended to use airtight containers to protect it from moisture and contaminants. Since it is a solid, it does not require refrigeration under normal laboratory conditions. General laboratory precautions include handling with care to avoid exposure to skin or inhalation. Always ensure proper ventilation when working with this compound to maintain a safe and controlled environment.

References cited in the TCI brochure

Daniel C. Salgueiro. Control of Redox‐Active Ester Reactivity Enables a General Cross‐Electrophile Approach to Access Arylated Strained Rings** Angewandte Chemie International Edition, 2022. doi:10.1002/anie.202205673