5-Iodouridine is a chemical compound classified under nucleosides, playing a crucial role in biochemical and biomedical research. It is widely used as a building block in the synthesis of various biological compounds, including pharmaceuticals and gene therapy molecules. In the laboratory, it is essential for studying the mechanisms of DNA and RNA transcription and translation. Its unique chemical structure allows it to interact with specific enzymes, making it a valuable tool for enzyme activity testing and molecular interaction studies.
The compound's structure is similar to natural nucleosides such as uridine, but with iodine substituting at the 5-position. This substitution imparts distinct reactivity and compatibility with certain enzymes, such as DNA polymerase. These properties make it a preferred choice for applications like oligonucleotide synthesis and diagnostic method development. Its chemical stability and solubility characteristics further enhance its utility in diverse laboratory settings.
In Indonesian laboratories, 5-Iodouridine is commonly used by researchers in biotechnology, pharmacology, and genetics. It is frequently involved in drug development projects, genetic mutation monitoring, and molecular effect studies. Its versatility and reliability make it a staple in both academic and industrial research environments, supporting advancements in life sciences and medical applications.
- Biochemical Research: 5-Iodouridine is used to study nucleic acid synthesis and enzyme interactions, aiding in understanding molecular mechanisms.
- Oligonucleotide Synthesis: Its chemical structure makes it ideal for synthesizing modified nucleic acids, which are essential in genetic engineering and diagnostics.
- Enzyme Activity Testing: The compound's ability to interact with DNA polymerase allows for accurate assessment of enzymatic activity in various biochemical assays.
- Diagnostic Development: It is employed in creating nucleotide-based diagnostic tools, supporting early disease detection and genetic screening.
- Gene Therapy Research: Its role in synthesizing therapeutic molecules supports the development of gene therapy applications in biotechnology.
| Brand | TCI |
|---|---|
| CAS number | 1024-99-3 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides |
| Pack sizes | Available in various quantities as per standard laboratory requirements |
| Physical form | Solid powder |
| Storage | Store in a cool, dry place away from light and moisture |
5-Iodouridine should be stored in a cool, dry place, away from direct light and moisture to maintain its chemical integrity. It is recommended to use airtight containers to prevent exposure to humidity and contaminants. Due to its chemical nature, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure laboratory safety. Avoid contact with incompatible substances, and ensure proper ventilation when working with the compound. Regular monitoring of storage conditions is advised to maintain its stability and effectiveness in research applications.
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