3-Mercapto-4-methyl-4H-1,2,4-triazole is a heterocyclic compound built around a triazole ring that carries a mercapto (thiol) group at position 3 and a methyl group on the nitrogen at position 4. The 1,2,4-triazole ring is a nitrogen-rich scaffold encountered very frequently in biologically active compounds as well as in functional materials. In the laboratory, this compound serves both as a heterocyclic building block and as a sulfur reagent — a material that donates a nucleophilic sulfur atom to form carbon–sulfur bonds during the early stages of assembling more complex molecules.
The characteristics that make this material valuable are the thiol–thione equilibrium on the triazole ring together with the combination of several donor atoms within a single small molecule. The sulfur atom is strongly nucleophilic, so it readily undergoes S-alkylation with alkyl and benzyl halides, yielding thioether derivatives efficiently. The ring nitrogen atoms, meanwhile, are able to coordinate with metal ions, which makes the compound an attractive ligand for complex formation as well as for metal surface applications. The methyl group on the nitrogen fixes the substitution pattern, so the resulting derivatives are better defined and no mixture of N-alkylation isomers is produced.
In Indonesian laboratories, this building block is typically used in synthetic organic chemistry groups at universities and research institutes, as well as in development laboratories that prepare heterocyclic intermediates. It is handled at the bench scale in workflows that require a defined sulfur donor for constructing carbon–sulfur bonds, and in coordination chemistry work where a small nitrogen-rich ligand is needed. TCI packaging suits this kind of work, where reagents are consumed across a series of small exploratory reactions rather than in bulk.
Related TCI products
- TCI A1455 16691-43-3 3-Amino-5-mercapto-1,2,4-triazole
- TCI A0956 1750-12-5 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole [for Determination of Aldehydes]
- TCI M0847 59032-27-8 5-Mercapto-1H-1,2,3-triazole Sodium Salt
- TCI M0814 3179-31-5 3-Mercapto-1,2,4-triazole
- TCI A0425 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole
- TCI P0640 86-93-1 5-Mercapto-1-phenyl-1H-tetrazole
- S-alkylation reactions to form thioethers: the strongly nucleophilic sulfur atom reacts readily with alkyl and benzyl halides, giving thioether derivatives efficiently without requiring aggressive activation of the substrate.
- Heterocyclic building block in multistep synthesis: the preformed 1,2,4-triazole ring provides a nitrogen-rich scaffold directly, so chemists can begin from an intact core rather than constructing the ring themselves.
- Sulfur donor reagent for carbon–sulfur bond formation: the compound supplies a nucleophilic sulfur atom at early synthetic stages, making it useful wherever a defined C–S linkage must be installed on more complex targets.
- Ligand preparation for metal coordination complexes: the ring nitrogen atoms coordinate with metal ions, allowing the molecule to act as a compact, nitrogen-rich ligand in complex formation studies.
- Metal surface treatment studies: the same combination of sulfur and nitrogen donor atoms in one small molecule makes it relevant for laboratory work involving interactions between heterocyclic thiols and metal surfaces.
| Brand | TCI |
|---|---|
| CAS number | 24854-43-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in TCI catalogue pack sizes; please confirm the currently listed options when ordering |
| Physical form | — |
| Storage | — |
- Product code: M1224
- Chemical name: 3-Mercapto-4-methyl-4H-1,2,4-triazole
Store the container tightly closed in a cool, dry place away from direct sunlight, heat sources, and strong oxidising agents, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original supplier container, or in a clean, well-sealed glass or chemically compatible bottle if transferred, and label it clearly. Handle in a fume hood using gloves, safety goggles, and a laboratory coat, since thiol compounds may carry a strong odour. Weigh and transfer with clean, dry spatulas to avoid contamination, close the container immediately after use, and dispose of residues and contaminated materials in accordance with the applicable chemical waste procedures of your institution.
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