2'-O-(2-Methoxyethyl)uridine TCI M3954

Chemical Identity

CAS No.: 223777-15-9
Purity: >95.0%(HPLC)(T)

Rp 3.153.150,00

~~Rp 2.220.750,00~~ Rp 3.153.150,00

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2'-O-(2-Methoxyethyl)uridine from TCI is a modified pyrimidine nucleoside carrying a 2-methoxyethyl group at the 2'-position of the ribose sugar, completing the MOE nucleoside series that forms the backbone of contemporary therapeutic oligonucleotide chemistry. As the pyrimidine counterpart to the corresponding adenosine derivative, this compound supplies the uracil base unit required to assemble fully modified oligonucleotide strands. In the laboratory it serves as a starting material for the preparation of phosphoramidite monomers, as an analytical reference material, and as a study compound in research on chemical modification of nucleic acids aimed at improving strand durability and binding affinity.

The properties that make this compound highly valued are the influence of the methoxyethyl group on sugar conformation and on the biological stability of the strand. The substituent at the 2'-position directs the sugar ring toward a conformation that favours duplex formation with RNA, so binding strength toward the target sequence increases and the resulting duplex becomes more stable against heat. At the same time, the space occupied by that group hinders nuclease enzymes from reaching the neighbouring phosphodiester linkages, which extends the working life of the modified strand. This combination of higher affinity and greater resistance is the reason MOE chemistry has become a standard reference point in the field.

In Indonesian laboratories, the material is typically handled in university research groups, biotechnology institutes, and analytical service laboratories working on nucleic acid chemistry. It is used in small quantities for synthetic route development, method validation, and teaching at the postgraduate level, where a well-characterised commercial nucleoside removes the need for in-house preparation. Researchers usually order it alongside related MOE nucleosides so that a complete set of base units is available for a given synthesis programme.

Related TCI products

Phosphoramidite monomer synthesis: the free nucleoside provides the protected-precursor starting point for building the activated monomers used in automated solid-phase oligonucleotide assembly.
Antisense oligonucleotide research: supplies the uracil-bearing MOE unit needed to construct fully modified strands whose affinity and nuclease resistance are being evaluated experimentally.
Analytical reference material: serves as an authentic standard for identity confirmation and method development in chromatographic and spectroscopic analysis of nucleoside mixtures.
Nucleic acid modification studies: functions as a model compound for investigating how 2'-substituents alter sugar puckering, duplex thermal stability, and hybridisation behaviour with RNA targets.
Postgraduate teaching and method training: gives synthesis and analysis courses a well-defined modified nucleoside for practical work in nucleic acid chemistry and instrumental characterisation.

Brand	TCI (Tokyo Chemical Industry)
CAS number	223777-15-9
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Pack sizes	available in research-scale unit packs; please confirm the currently offered size when ordering
Physical form	—
Storage	keep according to the storage condition stated on the manufacturer's label and certificate of analysis

Product code: M3954

Store the container tightly closed in a cool, dry place away from direct sunlight and moisture, following the storage condition printed on the manufacturer's label. Keep the material in its original supplier container, or transfer it to a clean, chemically compatible, well-sealed vial if subdividing is necessary. Allow refrigerated or frozen stock to reach room temperature before opening to avoid moisture condensation on the solid. Handle in a well-ventilated area or fume hood using gloves, safety glasses, and a laboratory coat, and avoid generating dust during weighing. Consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated items in accordance with applicable laboratory waste procedures.

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