1,2-Phenylenediamine from TCI, also known as o-phenylenediamine, is an aromatic diamine with two amino groups on adjacent positions of a benzene ring. It is one of the most widely used building blocks in organic chemistry. Because the two amino groups sit next to each other, the compound readily forms heterocyclic rings such as benzimidazoles, quinoxalines, and benzotriazoles. These ring systems are important scaffolds in drug research, dyes, and functional materials, so 1,2-Phenylenediamine is a common reagent in both synthetic and analytical laboratories.
Researchers choose this compound for its high and controllable reactivity. Both amino groups react with carboxylic acids, aldehydes, 1,2-dicarbonyl compounds, and nitrous acid to form rings in good yields, so it works reliably for building fused heterocyclic frameworks. The compound can also be oxidized to coloured and fluorescent products, and colorimetric and fluorometric detection methods make use of this behaviour. The same reactivity, however, makes it prone to discoloration on exposure to air and light. Careful storage is needed to keep its quality consistent from one experiment to the next.
In Indonesia, 1,2-Phenylenediamine is widely used in organic chemistry laboratories at universities, both for teaching practicals and for student and faculty research projects on heterocyclic synthesis. Pharmaceutical and medicinal chemistry research groups use it to prepare benzimidazole and quinoxaline derivatives for biological screening. Analytical laboratories value it as a reagent for colorimetric and fluorometric methods. With the TCI brand behind it, laboratories can rely on a well-documented, consistent source for routine and research work.
TCI brochures (PDF)
- Colloidal Quantum Dot (QD) Research Reagents 2026-05-21 · p. 8
Related TCI products
- Benzimidazole synthesis: the adjacent amino groups condense efficiently with carboxylic acids or aldehydes, giving benzimidazole cores that are widely studied in medicinal chemistry.
- Quinoxaline preparation: reacting the compound with 1,2-dicarbonyl compounds forms quinoxaline rings in good yields, which suits research on dyes, functional materials, and bioactive molecules.
- Benzotriazole formation: treating the compound with nitrous acid closes a triazole ring on the benzene core, making it a direct and practical route to benzotriazole derivatives.
- Colorimetric and fluorometric detection: the compound oxidizes to coloured and fluorescent products, so analytical laboratories use it as a sensitive reagent in detection methods.
- Teaching and research practicals: its predictable ring-forming reactions make it a good choice for university organic chemistry courses that demonstrate heterocyclic synthesis to students.
| Brand | TCI (product code P0968) |
|---|---|
| CAS number | 95-54-5 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in the pack sizes listed on the product page |
| Physical form | — |
| Storage | protect from air and light to prevent discoloration |
- Chemical type: aromatic diamine (o-phenylenediamine)
Keep 1,2-Phenylenediamine in a tightly closed original container, protected from air and light, because exposure causes discoloration and loss of quality. Store it in a cool, dry, well-ventilated area away from oxidizing agents. Amber or opaque containers help limit light exposure, and flushing the headspace with an inert gas after each use can help preserve opened stock. Handle the material in a fume hood while wearing suitable gloves, safety glasses, and a laboratory coat. Avoid inhaling dust and avoid contact with skin. Always consult the supplier's Safety Data Sheet before use, and dispose of waste according to institutional and local regulations.
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