4-Phenylcyclohexanone from TCI is a cyclic ketone made of a cyclohexanone ring with a phenyl group at the 4-position. It combines a six-membered aliphatic ring with an aromatic ring, which makes it a versatile building block for constructing more complex molecular frameworks. In the laboratory, chemists use it to synthesize intermediates for medicinal chemistry research and liquid crystal materials. It is also used in conformational studies of the cyclohexane ring, where its well-defined structure gives researchers a dependable starting point for both synthetic and mechanistic work.
Researchers prefer this compound mainly because the phenyl group at the 4-position tends to sit in the equatorial position. This keeps the ring in a fairly fixed conformation, so the compound is an ideal substrate for studying the stereoselectivity of reactions at the carbonyl group. A common example is comparing axial and equatorial attack during reduction. The ketone group is also easy to convert through reductive amination, Wittig reactions, or enolate formation. In addition, the molecule's symmetry makes NMR spectra easier to interpret, which helps both teaching and research laboratories.
For laboratories in Indonesia, 4-Phenylcyclohexanone is useful for teaching and research in advanced organic chemistry, especially in stereochemistry and conformational analysis. University chemistry departments can use it to show how a fixed ring conformation affects the outcome of a reaction. Medicinal chemistry and materials researchers who need a cyclohexane scaffold carrying an aromatic substituent will also find it useful. Its predictable reactivity makes it a good fit for both training students and running exploratory synthesis programs.
- Stereoselectivity studies of carbonyl reduction: the equatorial phenyl group locks the ring conformation, so researchers can clearly separate and compare axial attack from equatorial attack.
- Synthesis of medicinal chemistry intermediates: the phenyl-substituted cyclohexane framework is a useful scaffold for building more complex candidate molecules in drug discovery research.
- Liquid crystal material research: the combination of an aliphatic ring and an aromatic ring makes it a suitable precursor for building molecular structures used in liquid crystal studies.
- Ketone functionalization reactions: the carbonyl group reacts readily in reductive amination, Wittig olefination, and enolate chemistry, so the compound can lead to many different derivatives.
- Teaching NMR spectroscopy and conformational analysis: the symmetrical molecular structure gives spectra that are easier to interpret, which helps students learn the relationship between structure and signals.
| Brand | TCI (product code P0975) |
|---|---|
| CAS number | 4894-75-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in the pack sizes listed by TCI for this product code |
| Physical form | refer to the TCI product specification and certificate of analysis |
| Storage | keep tightly closed in a cool, dry place as directed on the manufacturer's label |
Store 4-Phenylcyclohexanone in its original, tightly sealed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and strong oxidizing agents. If you transfer the material, use clean glass or chemically compatible containers that are clearly labeled with the product name and CAS number. Handle it in a fume hood or a well-ventilated area, and wear standard personal protective equipment, including safety glasses, nitrile gloves, and a lab coat. Avoid creating dust or inhaling vapors, and avoid contact with skin and eyes. Always read the manufacturer's Safety Data Sheet before use, and dispose of residues according to local chemical waste regulations.
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