TCI P2394 Pentafluoroethanesulfonamide (CAS 78491-70-0) is a sulfonamide with a pentafluoroethyl (C2F5) chain bonded to the sulfonyl group, which makes it a distinctive organofluorine compound. In the laboratory it is used as a fluorinated building block, a starting material for introducing the perfluoroalkylsulfonyl group into target molecules. Researchers use it to prepare fluorinated sulfonimides, sulfonamide derivatives for medicinal chemistry, and precursors to salts and ionic liquids studied for electrolytes and functional materials.
The perfluoroalkyl chain strongly withdraws electrons, so the hydrogen atoms on the NH2 group are much more acidic than in ordinary sulfonamides. This makes deprotonation easier and allows further reactions at the nitrogen atom, such as forming asymmetric imides with other sulfonyl groups. The perfluoroalkylsulfonimide anions made this way are known to be stable and to have a delocalized charge, which is why they are wanted for battery electrolytes and ionic liquids. The fluorinated group can also change a molecule's lipophilicity and metabolic stability, both of which matter when designing bioactive compounds.
In Indonesian laboratories, this compound is relevant to university and research-institute groups working on battery research, energy storage materials, and organofluorine synthesis. Chemistry departments working on new electrolyte salts, ionic liquids, or fluorinated drug candidates can use it as a reliable starting material for synthetic routes. Because the product comes from the TCI brand, researchers can document a consistent source of the reagent across repeated experiments, theses, and collaborative research projects.
- Synthesis of fluorinated sulfonimides: the acidic NH2 group deprotonates easily and reacts with other sulfonyl groups, giving asymmetric perfluoroalkylsulfonimides with stable, delocalized anions.
- Preparation of electrolyte salts for battery research: the perfluoroalkylsulfonimide anions made from this building block have the stability and charge delocalization that electrolyte formulations need.
- Development of ionic liquids: the compound is a precursor to salts whose fluorinated anions are studied in ionic liquids and functional materials across materials chemistry research.
- Medicinal chemistry derivatization: the pentafluoroethylsulfonyl group can be added to drug-like scaffolds to study how fluorination affects lipophilicity and metabolic stability.
- General organofluorine methodology: the compound gives synthetic chemists a convenient way to bring a C2F5-sulfonyl unit into new molecules when exploring reactions at an activated sulfonamide nitrogen.
| Brand | TCI (product code P2394) |
|---|---|
| CAS number | 78491-70-0 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | available in the pack sizes offered by TCI for this product code |
| Physical form | refer to the TCI product specification and certificate of analysis |
| Storage | keep in a tightly closed original container, following the conditions stated on the TCI label |
Store Pentafluoroethanesulfonamide in its original, tightly sealed container in a cool, dry, well-ventilated chemical storage area, away from moisture, direct sunlight, and incompatible substances such as strong bases and strong oxidizing agents. Always follow the storage conditions given on the TCI label and safety data sheet. Handle it in a fume hood and wear suitable gloves, safety glasses, and a lab coat. Avoid breathing dust or vapors and avoid contact with skin and eyes. Label secondary containers clearly, and dispose of residues and contaminated materials as fluorinated chemical waste according to institutional and local regulations.
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