ULTROXA(regR) Poly(2-ethyl-2-oxazoline) (n=approx. 100) TCI P2507

Chemical Identity

CAS No.: 161358-47-0

Rp 5.432.700,00

~~Rp 3.798.900,00~~ Rp 5.432.700,00

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Berat 500mg

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ULTROXA(regR) Poly(2-ethyl-2-oxazoline) is a versatile chemical compound widely used in pharmaceutical research and development laboratories. As a polymer with a molecular weight of approximately 100, it plays a crucial role in drug delivery systems by enabling controlled release of active pharmaceutical ingredients. Its unique structure allows it to interact with various molecules, making it an essential tool for researchers aiming to enhance drug efficacy and stability. This material is commonly used in the formulation of advanced drug delivery systems, supporting the development of targeted and sustained-release therapies.

The key properties that make ULTROXA(regR) a preferred choice include its hydrophilic nature and ability to form complexes with a wide range of active compounds. These characteristics allow it to improve the solubility and bioavailability of drugs, which is critical in the development of effective therapeutic agents. Additionally, its biocompatibility ensures that it is safe for use in medical and pharmaceutical applications, reducing the risk of adverse reactions. These features make it a reliable and efficient component in the creation of innovative drug delivery solutions.

In Indonesian laboratories, ULTROXA(regR) is frequently utilized in research focused on drug development and delivery systems. It is a popular choice among researchers in academic institutions and research centers due to its effectiveness in enhancing drug performance and prolonging therapeutic effects. Its application is particularly relevant in the study of controlled release mechanisms and the improvement of drug stability under various conditions.

Advantages (TCI brochure)

Biocompatible and non-immunogenic pseudo-polypeptide structure
Transitions to a hydrophobic state in water when heated
LCST ca. 65°C

TCI brochures (PDF)

Water-soluble Biocompatible Polymers Poly(2-oxazoline)s 2024-08-21 · p. 1
Water-solubility Enhancing Agents Superior to PEGs 2025-04-03 · p. 1
Drug Delivery System (DDS) Research Reagents 2025-01-29 · p. 4
Biomaterials Research Reagents 2025-02-19 · p. 5

Related TCI products

Drug Delivery System Development: ULTROXA(regR) is ideal for designing controlled release formulations due to its ability to modify drug release kinetics.
Pharmaceutical Formulation Research: Its hydrophilic properties make it suitable for improving the solubility and bioavailability of poorly soluble drugs.
Biocompatibility Testing: The material’s biocompatible nature makes it useful in assessing the safety of new drug delivery systems in preclinical studies.
Active Ingredient Complexation Studies: It enables the formation of stable complexes with various therapeutic agents, enhancing drug stability and targeting.
Controlled Release Mechanism Optimization: Its structural versatility supports the development of sustained release profiles for improved therapeutic outcomes.

From the TCI brochure

Surface coating with protein-repellent or nonfouling properties
Drug delivery systems
Thermoresponsive material

Brand	TCI
CAS number	161358-47-0
Molecular formula	—
Purity	—
Category	Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Pack sizes	—
Physical form	—
Storage	Store in a cool, dry place away from direct sunlight

Data from the TCI brochure

LCST	ca. 65°C

Source: TCI brochure LL059 (2024-08-21)

ULTROXA(regR) should be stored in a cool, dry environment to maintain its chemical integrity and prevent degradation. It is recommended to use airtight containers to minimize exposure to moisture and contaminants. Since it is a polymer, it should be kept away from sources of heat and direct sunlight to avoid any physical or chemical changes. In laboratory settings, it is important to handle the material with appropriate personal protective equipment to ensure safety. Regular monitoring of storage conditions is advised to ensure the material remains suitable for use in pharmaceutical research applications. Proper labeling and storage practices help maintain the quality and effectiveness of the compound for ongoing research projects.

References cited in the TCI brochure

Rupert Konradi. Poly-2-methyl-2-oxazoline: A Peptide-like Polymer for Protein-Repellent Surfaces Langmuir, 2008. doi:10.1021/la702917z
Rupert Konradi. Polyoxazolines for Nonfouling Surface Coatings — A Direct Comparison to the Gold Standard PEG Macromolecular Rapid Communications, 2012. doi:10.1002/marc.201200422
Tacey X. Viegas. Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery Bioconjugate Chemistry, 2011. doi:10.1021/bc200049d
Herdis Bludau. POxylation as an alternative stealth coating for biomedical applications European Polymer Journal, 2017. doi:10.1016/j.eurpolymj.2016.10.041
Richard Hoogenboom. Tuning the LCST of poly(2-oxazoline)s by varying composition and molecular weight: alternatives to poly(N-isopropylacrylamide)? Chemical Communications, 2008. doi:10.1039/b813140f
Marcel A. Boerman. Synthesis of pH‐ and thermoresponsive poly(2‐n‐propyl‐2‐oxazoline) based copolymers Journal of Polymer Science Part A: Polymer Chemistry, 2016. doi:10.1002/pola.28011
Maarten Mees. Partially Hydrolyzed Poly(n-propyl-2-oxazoline): Synthesis, Aqueous Solution Properties, and Preparation of Gene Delivery Systems Biomacromolecules, 2016. doi:10.1021/acs.biomac.6b01088