Rotenone TCI R0090

Chemical Identity

CAS No.: 83-79-4
PubChem: CID 6758·SID 135727168
Formula: C23H22O6
Molecular weight: 394.4 g/mol
Purity: >95.0%(HPLC)
Reference databases: ChEBI·ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one
SMILES: CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC
InChIKey: JUVIOZPCNVVQFO-HBGVWJBISA-N

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Rotenone is a chemical compound widely used in scientific experiments, particularly in biochemistry and disease research. It plays a crucial role in preparing animal disease models, especially in studies related to oxidative stress and mitochondrial metabolic disorders. This compound is essential for understanding the mechanisms behind neurodegenerative diseases and metabolic conditions. Its ability to inhibit mitochondrial complex I in the electron transport chain makes it a valuable tool for researchers aiming to replicate and study disease pathways in controlled environments.

Rotenone is preferred due to its chemical stability under specific conditions and its effectiveness in interacting with biological systems. It is sensitive to light and moisture, which requires careful handling and storage. Its complex molecular structure enables consistent and measurable biological effects, making it a reliable reagent for various experimental setups. Researchers rely on its predictable behavior to ensure reproducibility in their studies, which is vital for scientific accuracy and progress.

In Indonesian laboratories, rotenone is commonly used in pharmacology, biomedical, and toxicological research. It is integral to experiments involving toxic effect testing on test animals and the study of disease mechanisms. Its application supports both basic and applied research, contributing to advancements in understanding and treating various health conditions. The compound's versatility and reliability make it a key component in the scientific toolkit of Indonesian researchers.

Related TCI products

Oxidative Stress Studies - Rotenone is used to induce oxidative stress in cell cultures to study its effects on cellular function and antioxidant responses.
Mitochondrial Dysfunction Research - It is a key reagent for investigating mitochondrial impairments and their role in neurodegenerative diseases.
Toxicological Testing - Rotenone is employed in assessing the toxicity of compounds on animal models, providing insights into potential harmful effects.
Pharmacological Screening - It is used to evaluate the efficacy of drugs in modulating mitochondrial function and metabolic pathways.
Disease Model Development - Rotenone helps in creating accurate animal models for studying metabolic and neurodegenerative disorders.

Brand	TCI
CAS number	83-79-4
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Animal Disease Models Preparation
Pack sizes	Available in various quantities as per supplier specifications
Physical form	Solid powder
Storage	Store in a cool, dark place away from light and moisture

Rotenone should be stored in a cool, dark environment to prevent degradation due to light and moisture exposure. It is recommended to use airtight containers made of glass or inert plastic to maintain its stability. Laboratory personnel should wear appropriate personal protective equipment when handling this compound to ensure safety. Due to its potential toxicity, it should be handled in a fume hood to minimize inhalation risks. Proper labeling and storage conditions are essential to maintain its effectiveness and ensure safe usage in research settings.

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