Spermidine Phosphate from TCI is the phosphate salt of spermidine, a naturally occurring polyamine found in almost all living cells. Spermidine takes part in many cellular processes, including nucleic acid stabilization, regulation of cell growth, protein synthesis, and autophagy. In the laboratory, this compound is classed as a bioactive small molecule. It is used in cell biology, biochemistry, and molecular biology research to study the roles of polyamines, and as an additive in a range of enzymatic reactions.
The phosphate salt is generally preferred because it is easier to handle than spermidine free base. The free base tends to be hygroscopic and can absorb carbon dioxide from the air. As a salt, the material is more practical to weigh accurately, which supports reproducible solution preparation. At physiological pH, spermidine carries a positive charge, so it can interact with negatively charged DNA and RNA. This interaction helps compact and stabilize nucleic acids. That property is the reason spermidine is often used in in vitro transcription reactions and in many molecular biology protocols.
In Indonesian laboratories, Spermidine Phosphate is useful to researchers in biotechnology, medicine, and molecular biology at universities and research institutions. Research groups studying cellular processes such as growth regulation and autophagy can use it to investigate polyamine function. Molecular biology laboratories can include it as a reaction additive where nucleic acid stabilization matters. Because the salt form is convenient to weigh and handle, it suits both routine teaching laboratories and more advanced research settings where consistent results are important.
TCI brochures (PDF)
- Xylem Differentiation-Inducing Polyamine Xylemin 2024-11-15 · p. 2
- Polyamines 2025-10-21 · p. 2
- Reagents for Biological Research 2025-03-11 · p. 59
Related TCI products
- Polyamine research: researchers use it to study the biological roles of polyamines, because spermidine occurs naturally in almost all living cells and takes part in key cellular processes.
- In vitro transcription: it is commonly added to transcription reactions, because its positive charge lets it interact with and stabilize negatively charged DNA and RNA templates and products.
- Nucleic acid stabilization studies: it suits experiments on DNA and RNA compaction, because the positively charged spermidine binds nucleic acids and helps condense and stabilize them.
- Autophagy and cell growth research: it supports cell biology investigations into autophagy and the regulation of cell growth, both processes in which spermidine is known to take part.
- Enzymatic reaction additive: it is used as an additive in a range of enzymatic and molecular biology protocols, where the easily weighed phosphate salt allows accurate and reproducible preparation.
| Brand | TCI (product code S0068) |
|---|---|
| CAS number | 259244-14-9 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Cell Biology > Bioactive Small Molecules |
| Pack sizes | available in the pack sizes offered by TCI; please confirm when ordering |
| Physical form | — |
| Storage | keep tightly closed and protected from moisture and air; follow the manufacturer's label and SDS |
- Chemical form: phosphate salt of spermidine
Store Spermidine Phosphate in its original, tightly sealed container in a cool, dry, well-ventilated place. Keep it away from moisture and direct sunlight, and always follow the specific storage conditions on the TCI label and safety data sheet. Close the container promptly after use to limit exposure to air and humidity. When handling the material, wear standard laboratory protective equipment such as gloves, safety glasses, and a lab coat. Avoid creating dust, and weigh the material in a clean, dry environment. Label prepared solutions clearly and dispose of waste in line with local laboratory regulations.
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