Spermine Phosphate Hexahydrate TCI S0069

Chemical Identity

CAS No.: 58298-97-8
PubChem: CID 517358·SID 87575693
Formula: C10H32N4O8P2
Molecular weight: 398.33 g/mol
Purity: >98.0%(N)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: N,N'-bis(3-aminopropyl)butane-1,4-diamine;phosphoric acid
SMILES: C(CCNCCCN)CNCCCN.OP(=O)(O)O.OP(=O)(O)O
InChIKey: GOQWEECJRRZEHR-UHFFFAOYSA-N

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Spermine Phosphate Hexahydrate from TCI is a hydrated phosphate salt of spermine, a naturally occurring polyamine with four amine groups that is found in eukaryotic cells. In living systems, spermine helps stabilise the structure of DNA and RNA, regulates ion channels, protects cells against oxidative stress, and takes part in controlling cell growth. In the laboratory it is classed as a bioactive small molecule and is used in cell biology, molecular biology, biophysics, and biochemistry research. It is especially useful in work on polyamine function and on how small molecules interact with nucleic acids.

At physiological pH all four of spermine's amine groups are protonated, so it carries a higher positive charge than spermidine. Because of this, it binds nucleic acids more strongly, which makes it very effective at condensing DNA and at helping nucleic acids crystallise. The phosphate hexahydrate salt is chosen because it is generally more stable and easier to weigh than the free base. The free base is hygroscopic and reacts with carbon dioxide in the air. Researchers also use this compound as a modulator in studies of ion channels and certain receptors, so it has a place in both structural and functional work.

In Indonesian laboratories, Spermine Phosphate Hexahydrate is used in molecular biology, medical, and life science research. University research groups, institutes, and biomedical laboratories can use it to study how polyamines affect nucleic acid structure, cell proliferation, and responses to oxidative stress. Its stable salt form makes it practical in tropical climates, where high humidity can make hygroscopic reagents hard to handle. It suits routine experimental protocols as well as more specialised structural biology work.

TCI brochures (PDF)

Polyamines 2025-10-21 · p. 2
Reagents for Biological Research 2025-03-11 · p. 59

Related TCI products

DNA condensation studies: the four protonated amine groups give spermine a strong positive charge, so it compacts DNA effectively in biophysical and molecular biology experiments.
Nucleic acid crystallisation: spermine binds strongly to nucleic acids and stabilises them, which helps produce ordered DNA and RNA crystals for structural analysis.
Polyamine function research: as a natural eukaryotic polyamine, spermine is a direct reference compound for studying the roles of polyamines in cell growth and cell regulation.
Ion channel and receptor modulation: spermine is used as a modulator in studies of ion channels and certain receptors, which helps researchers understand how these proteins are regulated in cell biology.
Oxidative stress studies: spermine is known to help protect cells against oxidative stress, so it is useful in experiments on how cells defend themselves against oxidative damage.

Brand	TCI (product code S0069)
CAS number	58298-97-8
Molecular formula	—
Purity	—
Category	Life Science > Cell Biology > Bioactive Small Molecules
Pack sizes	available in the pack sizes TCI offers; please confirm current options with AMI Scientific
Physical form	—
Storage	keep the container tightly closed and follow the manufacturer's label and Safety Data Sheet

Chemical form: phosphate salt, hexahydrate, of spermine

Store Spermine Phosphate Hexahydrate in its original, tightly sealed container in a cool, dry place, away from direct sunlight, moisture, and incompatible substances. Follow the storage conditions on the TCI label and Safety Data Sheet. Close the container promptly after each use so the material picks up as little moisture and air as possible, which matters most in humid laboratory environments. Weigh the material with clean, dry tools, and prepare solutions with appropriate buffers just before use. During handling, wear standard personal protective equipment: laboratory gloves, safety glasses, and a lab coat. Avoid breathing in dust and avoid contact with skin and eyes. Work in a well-ventilated area, and dispose of waste according to institutional and local regulations.

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