Sodium Bromodifluoroacetate (TCI S0908, CAS 84349-27-9) is a chemical compound widely used in organic synthesis reactions, particularly in fluorination processes. This reagent plays a crucial role in laboratories by enabling the substitution of fluorine atoms on carbon chains, which is essential for the development of organofluorine compounds. Its unique chemical structure allows it to participate in various synthetic pathways, making it a valuable tool for researchers aiming to create compounds with specific functional properties.
The compound is known for its high reactivity, especially under elevated temperatures or in polar solvents, which makes it a preferred choice for controlled chemical transformations. Its solubility in organic solvents such as ethyl acetate and acetone further enhances its usability in laboratory settings. These properties enable chemists to manipulate molecular structures with precision, contributing to the synthesis of compounds with desired stability, polarity, or reactivity.
In Indonesian laboratories, Sodium Bromodifluoroacetate is commonly used by researchers in fields such as organic chemistry, pharmacology, and materials science. Its application in drug development and the creation of specialized materials underscores its importance in both academic and industrial research. Due to its reactivity, it requires careful handling and precise reaction conditions to ensure optimal results and safety.
TCI brochures (PDF)
- Difluorocarbene Precursors 2015-02-19 · p. 1
- Difluoromethylation Reagents, Difluoromethylenation Reagents 2026-05-18 · p. 2
- Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 8
- Organic synthesis reactions where fluorine substitution is required for creating organofluorine compounds.
- Fluorination processes in pharmaceutical research to develop compounds with enhanced stability and bioavailability.
- Material science applications for synthesizing fluorinated polymers and specialty materials with unique properties.
- Analytical chemistry experiments involving the study of fluorinated compounds and their reactivity under different conditions.
- Research in environmental chemistry to investigate the behavior and degradation of fluorinated substances in natural systems.
From the TCI brochure
- Difluorocarbene (:CF2) precursor for cyclopropanation of alkenes with heating, shown together with C0991 (Oshiro, Morimoto, Amii, Synthesis 2010)
| Brand | TCI |
|---|---|
| CAS number | 84349-27-9 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Synthetic Reagents > Fluorination Reagents |
| Pack sizes | Available in various sizes as per supplier specifications |
| Physical form | Solid or crystalline, depending on the batch |
| Storage | Store in a cool, dry place away from moisture and direct sunlight |
Data from the TCI brochure
| Kemasan | 5 g |
|---|
Source: TCI brochure RR029 (2015-02-19)
Sodium Bromodifluoroacetate should be stored in a cool, dry environment to maintain its chemical integrity. It is recommended to keep it in a sealed container to prevent exposure to moisture and air, which can affect its reactivity. Due to its high reactivity, it should be handled with appropriate personal protective equipment, including gloves and safety goggles. Storage should be in a well-ventilated area, away from incompatible substances such as strong oxidizers. Proper labeling and adherence to standard laboratory safety protocols are essential to ensure safe handling and usage in research environments.
References cited in the TCI brochure
- Hideki Amii. Sodium Bromodifluoroacetate: A Difluorocarbene Source for the Synthesis of gem-Difluorocyclopropanes Synthesis, 2010. doi:10.1055/s-0029-1218754
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