Tetrabutylammonium Fluoride Hydrate [for Catalyst of silylation and cleavage of silyl ether] TCI T1037

Chemical Identity

CAS No.: 22206-57-1
PubChem: CID 2724141·SID 87576839
Formula: C16H36FN
Molecular weight: 261.46 g/mol
Purity: >98.0%(T)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: tetrabutylazanium fluoride
SMILES: CCCC[N+](CCCC)(CCCC)CCCC.[F-]
InChIKey: FPGGTKZVZWFYPV-UHFFFAOYSA-M

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TCI T1037 is Tetrabutylammonium Fluoride Hydrate, CAS number 22206-57-1, which the TCI catalogue describes as a material for the catalyst of silylation and cleavage of silyl ether. It is a quaternary ammonium salt that supplies fluoride ions in a form soluble in organic solvents. For this reason it is one of the most widely used fluoride reagents in synthetic organic chemistry laboratories, especially for removing silyl protecting groups from hydroxyl groups.

The main advantage of this reagent is the large, lipophilic tetrabutylammonium cation, which carries the fluoride ion into the organic phase so that it can react effectively. The high affinity of fluoride for silicon is the basis of its action: the silicon-oxygen bond is broken and the protecting group is released. The hydrate form means the reagent contains water, which matters when a reaction demands strictly dry conditions. The material is also hygroscopic, so it should be handled quickly and stored tightly closed.

In Indonesia, organic synthesis laboratories, natural product research groups, and medicinal chemistry teams often need this reagent for the final deprotection steps of a synthetic route. It is also used where silylation or silyl ether cleavage must be catalysed under mild conditions. AMI Scientific supplies this TCI product in 25g and 100g pack sizes for such laboratory work.

TCI brochures (PDF)

Halogenation Reagents 2026-04-03 · p. 5
Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 7

Related TCI products

Silyl ether deprotection: the fluoride ion has a strong affinity for silicon, so this reagent cleaves the silicon-oxygen bond and releases the free hydroxyl group in the final stages of a synthesis.
Catalysis of silylation: the catalogue lists this material as a catalyst for silylation, and its organic-soluble fluoride ion makes it convenient to use in reaction mixtures prepared in organic solvents.
Natural product research: multi-step syntheses of complex molecules often rely on silyl protecting groups, and this reagent allows those groups to be removed at the end without a harsh acidic or basic treatment.
Medicinal chemistry: when building candidate compounds that carry protected hydroxyl groups, the reagent gives chemists a dependable way to reveal those groups after the other synthetic transformations are complete.
Fluoride-based synthetic methods: as a member of the fluorination reagents category, it serves as a convenient source of soluble fluoride ion for research laboratories exploring reactions that need fluoride in an organic medium.

Brand	TCI
CAS number	22206-57-1
Molecular formula	—
Purity	—
Category	Chemistry > Synthetic Reagents > Fluorination Reagents [Synthetic Reagents]
Pack sizes	25g and 100g
Physical form	—
Storage	hygroscopic hydrate; keep tightly closed and handle quickly

Product code: T1037

Because Tetrabutylammonium Fluoride Hydrate is hygroscopic, keep the container tightly closed and return it to storage immediately after use to limit moisture uptake. Store it in its original manufacturer container, in a cool, dry place away from incompatible materials. Weigh and transfer the reagent promptly, and remember that the water content of the hydrate may affect reactions that require dry conditions. Follow general laboratory practice: wear gloves, safety glasses, and a lab coat, work in a well-ventilated area or fume hood, and avoid skin contact and inhalation. Consult the manufacturer's safety data sheet for detailed hazard and disposal guidance before use.

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