1,2,4-Trimethoxybenzene TCI T1130

Chemical Identity

CAS No.: 135-77-3
PubChem: CID 67284·SID 87576920
Formula: C9H12O3
Molecular weight: 168.19 g/mol
Purity: >97.0%(GC)
Reference databases: ChEBI·ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1,2,4-trimethoxybenzene
SMILES: COC1=CC(=C(C=C1)OC)OC
InChIKey: AGIQIOSHSMJYJP-UHFFFAOYSA-N

Rp 1.485.750,00

~~Rp 1.038.450,00~~ Rp 1.485.750,00

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Berat 25g

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TCI T1130 1,2,4-Trimethoxybenzene (CAS 135-77-3) is a benzene derivative carrying three methoxy groups at positions 1, 2, and 4 of the ring. In the laboratory it is used as a non-heterocyclic building block and as an electron-rich arene in a wide range of organic reactions. The methoxy substituents give the ring strong nucleophilic character, so the compound is often chosen as a model substrate or as a starting material for assembling more complex aromatic molecules.

The three methoxy groups are electron donors that activate the ring toward electrophilic aromatic substitution, for example Friedel-Crafts acylation, halogenation, or formylation. Because the substitution pattern is unsymmetrical, the molecule offers several possible reaction positions, which makes it an interesting case for studying regioselectivity. The methoxy groups can also be modified further, for instance by demethylation to give phenols. These characteristics make 1,2,4-trimethoxybenzene a convenient and versatile reagent for synthetic chemists who need a predictable, activated aromatic core.

In Indonesian laboratories, the 25 g pack suits repeated synthesis work, optimization experiments, and advanced organic chemistry practicals. That quantity leaves room for several trial reactions without the need to reorder after each experiment. Research groups, university teaching laboratories, and development teams can use it as a starting point for synthesizing oxygenated natural-product-type compounds, while the TCI brand gives users a familiar reference supplier for fine chemicals and building blocks.

Related TCI products

Electrophilic aromatic substitution studies: the three electron-donating methoxy groups strongly activate the ring, so this compound serves as a reactive substrate for acylation, halogenation, and formylation experiments.
Regioselectivity investigations: the unsymmetrical 1,2,4-substitution pattern offers several competing reaction positions, which makes it a useful model for teaching and for research into how substituents direct incoming groups.
Building block for oxygenated aromatic compounds: as a non-heterocyclic building block, it provides a ready-made, electron-rich aromatic core from which more elaborate natural-product-type molecules can be constructed.
Demethylation to phenols: the methoxy groups can be cleaved selectively or fully, allowing chemists to prepare phenolic derivatives from a stable, easily handled starting material.
Advanced organic chemistry practicals: a 25 g pack gives enough material for repeated runs and optimization experiments, so students and researchers can compare conditions without interrupting their work to reorder.

Brand	TCI (product code T1130)
CAS number	135-77-3
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	25 g
Physical form	—
Storage	keep tightly closed in a cool, dry place, away from incompatible materials, and follow the supplier's label and safety data sheet

Chemical name: 1,2,4-Trimethoxybenzene

Store 1,2,4-Trimethoxybenzene in its original, tightly closed container in a cool, dry, well-ventilated place, away from heat, direct sunlight, and strong oxidizing agents. Keep the label legible and record the date the bottle is first opened. Transfer only the amount needed, using clean and dry spatulas and glassware to avoid contamination. Handle the material in a fume hood or well-ventilated area, and wear a laboratory coat, safety glasses, and chemical-resistant gloves. Avoid inhaling dust or vapor and avoid contact with skin and eyes. Always consult the safety data sheet supplied with the product for specific hazard information and follow your institution's chemical waste procedures for disposal.

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