• 944453-80-9 2,4,6-Tris(trifluoromethyl)benzenesulfonyl Chloride - AMI Scientific
  • 944453-80-9 2,4,6-Tris(trifluoromethyl)benzenesulfonyl Chloride - AMI Scientific
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TCI

CAS 944453-80-9

2,4,6-Tris(trifluoromethyl)benzenesulfonyl Chloride TCI T4302

2,4,6-Tris(trifluoromethyl)benzenesulfonyl Chloride TCI T4302

Chemical Identity

CAS No.
944453-80-9
Purity
>95.0%(HPLC)(T)
Rp 3.949.050,00
Rp 3.949.050,00
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2,4,6-Tris(trifluoromethyl)benzenesulfonyl Chloride (CAS 944453-80-9) is a high-quality chemical from TCI, supplied as HPLC Grade.

Application: Used as a reactive acylating reagent in the synthesis of esters, amides, and sulfonamides.

Specifications:

  • Molecular formula: C9H2ClF9O2S
  • CAS number: 944453-80-9
  • Purity: >95.0%(HPLC)(T)
  • TCI product code: T4302

Synonyms: NmsCl

Available from AMI Scientific, the authorised TCI distributor in Indonesia. Contact us for pricing and stock availability — we ship throughout Indonesia.

Advantages (TCI brochure)

  • Allows protection and deprotection of various primary/secondary amines more efficiently and simply than Ns group.
  • Enables chemoselective deprotection.
  • Tolerable to competitive reactions.
  • Nms amides can be converted to amide or urea derivatives via deprotective functionalization.

TCI brochures (PDF)

Related TCI products

From the TCI brochure

  • Protecting group for primary and secondary amines
  • Pharmaceutical development: transformation of Nms-protected paroxetine into amide and urea derivatives

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Data from the TCI brochure

Protection yieldup to 99% (NmsCl [T4302], DMAP [D1450], Et3N [T0424], CH2Cl2, 20-25°C)
Deprotection yieldup to 99% (PhSH [B0041], K2CO3 [P1748], THF, 20-25°C)
Protection yield (indole amine example)92% (NmsCl [T4302], DMAP, Et3N, CH2Cl2, 20-25°C)
Deprotection yield (indole amine example)98% (PhSH, K2CO3, THF, 20-25°C)
Protection yield (nitrophenylpiperazine example)97% (NmsCl [T4302], DMAP, Et3N, CH2Cl2, 20-25°C)
Deprotection yield (nitrophenylpiperazine example)99% (PhSH, K2CO3, THF, 20-25°C)
Protection yield (duloxetine-derived example)92% (NmsCl [T4302], DMAP, Et3N, CH2Cl2, 20-25°C)
Deprotection yield (duloxetine-derived example)96% (PhSH, K2CO3, THF, 20-25°C)
Protection yield (paroxetine-derived example)98% (NmsCl [T4302], DMAP, Et3N, CH2Cl2, 20-25°C)
Deprotection yield (paroxetine-derived example)91% (PhSH, K2CO3, THF, 20-25°C)
Tolerance RMgXOK (Nms group)
Tolerance HydrideOK (Nms group)
Tolerance H2OK (Nms group, hydrogenation with H2 gas)

Source: TCI brochure RR217 (2025-07-10)

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References cited in the TCI brochure

  1. Philipp Spieß. Nms‐Amides: An Amine Protecting Group with Unique Stability and Selectivity Chemistry – A European Journal, 2023. doi:10.1002/chem.202301312
  2. Philipp Spieß. Deprotective Functionalization: A Direct Conversion of Nms‐Amides to Carboxamides Using Carboxylic Acids Angewandte Chemie International Edition, 2024. doi:10.1002/anie.202318304
  3. Philipp Spieß. Deprotective Lossen rearrangement: a direct and general transformation of Nms-amides to unsymmetrical ureas Chemical Science, 2024. doi:10.1039/d4sc04974h

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