Sulfur-Modified Pt/C Catalyst for Selective Hydrogenation Without Dehalogenation
Platinum 3% on Carbon (Modified by Sulfur) (Pt/C, TCI code: P3305) is a heterogeneous catalyst with 3 wt% platinum supported on activated carbon and poisoned with sulfur. It is used for chemoselective hydrogenation of nitro groups and olefins, particularly in substrates bearing halogen groups, because dehalogenation is almost completely suppressed.²) The catalyst suits both laboratory and process scale.²) In brochure examples, 2% P3305 under H2 0.2 MPa in MeOH at 30°C for 2 h gave 99.0% product with the halogen retained and only 0.8% dehalogenated byproduct for a halogen-substituted nitroarene. For a bromo nitroarene, 98.6% was retained with 0.7% byproduct after 3 h.²) A chlorinated alkenyl arene gave 99.1% halogen-retained product in 45 min at 0.1 MPa.²) The product is supplied wetted with ca. 50% water because it can be flammable when dried.
Related products
- TCI P3305 7440-06-4 Platinum 3% on Carbon (wetted with ca 55% Water) (Modified by Sulfur)
- TCI P3297 7440-05-3 Palladium 5% on Carbon, LA type (wetted with ca 55% Water)
- TCI P3298 7440-05-3 Palladium 5% on Carbon, LB type (wetted with ca 55% Water)
- TCI P3302 7440-05-3 Palladium 5% on Carbon, PH type (wetted with ca 55% Water)
- TCI P3293 7440-05-3 Palladium 5% on Carbon, AD type (wetted with ca 55% Water)
- TCI P3294 7440-05-3 Palladium 5% on Carbon, EA type (wetted with ca 55% Water)
- TCI P3295 7440-05-3 Palladium 5% on Carbon, EB type (wetted with ca 55% Water)
- TCI P3299 7440-05-3 Palladium 10% on Carbon, M type (wetted with ca 55% Water)
References
- Broad Survey of Selectivity in the Heterogeneous Hydrogenation of Heterocycles. T. W. Lyons, I. N. Leibler, C. Q. He, S. Gadamsetty, G. J. Estrada, A. G. Doyle, J. Org. Chem. 2024, 89, 1438. doi:10.1021/acs.joc.3c02028
- Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success. F. Lovering, J. Bikker, C. Humblet, J. Med. Chem. 2009, 52, 6752. doi:10.1021/jm901241e
Source
- TCI Product Highlights: www.tcichemicals.com/ID/en/product/tci-topics/ProductHighlights_20250428
- TCI product page P3305: tcichemicals.com/ID/en/p/P3305
- TCI product page P3297: tcichemicals.com/ID/en/p/P3297
- TCI product page P3298: tcichemicals.com/ID/en/p/P3298
- TCI product page P3302: tcichemicals.com/ID/en/p/P3302
- TCI product page P3293: tcichemicals.com/ID/en/p/P3293
- TCI product page P3294: tcichemicals.com/ID/en/p/P3294
- TCI brochure RR208: Precious Metal Catalysts on Activated Carbon for Heterogeneous Selective Hydrogenation
For research and laboratory use only, not for human consumption.
