Collection: Bicyclo[2.1.1]hexane Building Blocks

Bicyclo[2.1.1]hexane Building Blocks — includes structured bicyclic building blocks of bicyclo[2.1.1]hexane with protected amine, carboxylic acid, or boronate groups, serving as replacements for aromatic rings in drug molecule design based on sp3-rich scaffolds during the structure-activity relationship exploration stage.

Bicyclo[2.1.1]hexane building blocks such as methyl 4-aminobicyclo[2.1.1]hexane-1-carboxylate are used by medicinal chemists to replace phenyl or piperidine rings in lead optimization, improving the physicochemical properties and metabolism of compounds. Carboxylic acid and Boc-amine derivatives on this scaffold facilitate further conjugation in the parallel synthesis of drug candidates.

Example products in this collection: TCI P3128 Potassium Trifluoro[4-(methoxycarbonyl)bicyclo[2.1.1]hexan-1-yl]borate, TCI B6609 1050886-56-0 4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic Acid, TCI M3705 1638772-04-9 Methyl 4-Aminobicyclo[2.1.1]hexane-1-carboxylate Hydrochloride, TCI B6610 1050890-47-5 tert-Butyl (4-Aminobicyclo[2.1.1]hexan-1-yl)carbamate, TCI M3703 141046-52-8 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid.

Pay attention to the protecting groups (Boc, methyl ester, trifluoroborate) and salt forms (hydrochloride or free base), which determine compatibility with synthesis steps and subsequent derivatization pathways in the synthetic route. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Specialized Building Blocks for Drug Discovery, often used together in a single laboratory workflow:

• Bicyclo[1.1.1]pentane Building Blocks
• Cubane Building Blocks
• Bicyclo[3.1.1]heptane Building Blocks

Back to Specialized Building Blocks for Drug Discovery. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for stock availability checks and direct lead time information from Japan.