Collection: Bicyclo[1.1.1]pentane Building Blocks

Bicyclo[1.1.1]pentane Building Blocks — includes amine-, ester-, carboxylic acid-, and trifluoroborate-substituted bicyclo[1.1.1]pentane derivatives that serve as rigid three-dimensional scaffolds, acting as bioisosteric replacements for phenyl or tert-butyl rings. The distinctive cage structure provides unique bond angles and spatial distances that are difficult for conventional aromatic groups to achieve.

Compounds such as Bicyclo[1.1.1]pentan-1-amine Hydrochloride and Methyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate Hydrochloride are used by medicinal chemistry researchers as building blocks to replace aromatic rings in molecular design with different physicochemical and metabolic properties. Acid derivatives such as 3-Fluorobicyclo[1.1.1]pentane-1-carboxylic Acid and potassium trifluoroborate salts are also used in coupling reactions to expand compound libraries during the early discovery stage.

Example products in this collection: TCI B5479 22287-35-0 Bicyclo[1.1.1]pentan-1-amine Hydrochloride, TCI B6522 56842-95-6 Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid, TCI A3655 676371-65-6 Methyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate Hydrochloride, TCI B6523 1638767-25-5 tert-Butyl (3-Aminobicyclo[1.1.1]pentan-1-yl)carbamate, TCI P3127 2410559-74-7 Potassium Trifluoro[3-(methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]borate, TCI B6619 22287-28-1 Bicyclo[1.1.1]pentane-1-carboxylic Acid, TCI M3710 65862-01-3 3-Methylbicyclo[1.1.1]pentane-1-carboxylic Acid, TCI D6184 303752-38-7 3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid.

Pay attention to the terminal functional groups (amine, ester, carboxylic acid, or trifluoroborate) that determine the downstream synthesis route, as well as the salt form (hydrochloride or potassium trifluoroborate) that affects solubility and storage stability. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Specialized Building Blocks for Drug Discovery, often used together in one laboratory workflow:

• Cubane Building Blocks
• Bicyclo[2.1.1]hexane Building Blocks
• Bicyclo[3.1.1]heptane Building Blocks

Back to Specialized Building Blocks for Drug Discovery. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for availability checks and direct lead time from Japan.