Collection: Bicyclo[3.1.1]heptane Building Blocks

Bicyclo[3.1.1]heptane Building Blocks — covers bicyclo[3.1.1]heptane bicyclic building blocks bearing protected amine, carboxylic acid, or boronate groups, serving as replacements for aromatic rings or cyclohexane in drug molecule design based on sp3-rich scaffolds to increase the three-dimensional geometric diversity of compounds.

Bicyclo[3.1.1]heptane building blocks such as methyl 5-aminobicyclo[3.1.1]heptane-1-carboxylate are used by medicinal chemists as bioisosteres of cyclohexane or piperidine in the development of drug candidate compounds, helping to improve solubility and reduce excessive lipophilicity. Boc-amine and carboxylic acid derivatives on this scaffold facilitate further structural elaboration in fragment-based drug discovery programs.

Example products in this collection: TCI P3129 Potassium Trifluoro[5-(methoxycarbonyl)bicyclo[3.1.1]heptan-1-yl]borate, TCI B6607 1035325-28-0 5-[(tert-Butoxycarbonyl)amino]bicyclo[3.1.1]heptane-1-carboxylic Acid, TCI M3751 1824132-78-6 Methyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate, TCI B6608 1049607-15-9 tert-Butyl (5-Aminobicyclo[3.1.1]heptan-1-yl)carbamate, TCI M3701 110371-28-3 5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylic Acid.

Pay attention to the protecting groups and derivative forms (ester, free acid, potassium trifluoroborate salt) that suit the synthesis stage, as well as enantiomeric purity when specific stereochemistry of the target molecule is required. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Specialized Building Blocks for Drug Discovery, often used together in a single laboratory workflow:

• Bicyclo[1.1.1]pentane Building Blocks
• Cubane Building Blocks
• Bicyclo[2.1.1]hexane Building Blocks

Back to Specialized Building Blocks for Drug Discovery. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — for availability checks and lead times directly from Japan.