Collection: Heterobifunctional PEG and Oligoethylene Glycols

Heterobifunctional PEG and Oligoethylene Glycols — a collection of polyethylene glycol (PEG) or oligoethylene glycol chains with two different functional groups at each end, such as combinations of tetrazine, azide, alkyne, maleimide, or biotin. They function as heterobifunctional linkers that join two different molecules through two selective chemical reactions performed sequentially.

These heterobifunctional PEG linkers are used in bioconjugation to link proteins, peptides, or other carrier molecules through sequential reactions such as tetrazine-alkene ligation followed by maleimide-thiol reaction or biotin-streptavidin. The ethylene glycol chain also increases water solubility and provides spatial spacing between conjugated molecules, so it is widely used by bioconjugation researchers and imaging probe developers.

Example products in this collection: TCI T4298 2-[4-(1,2,4,5-Tetrazin-3-yl)phenyl]-N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]acetamide Hydrochloride, TCI B5665 756525-91-4 (Boc-amino)-PEG4-carboxylic Acid, TCI T4280 Tetrazine-amido-PEG3-Biotin, TCI B5900 581065-95-4 tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate, TCI T4279 2-[4-(1,2,4,5-Tetrazin-3-yl)phenyl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]acetamide, TCI B6081 1446282-43-4 Bromo-PEG3-Azide, TCI T4277 2-[4-(1,2,4,5-Tetrazin-3-yl)phenyl]-N-[2-[2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy]ethyl]acetamide, TCI B6093 1347750-75-7 (Boc-amino)-PEG3-C2-Carboxylic Acid.

Pay attention to the combination of functional group pairs at both ends of the chain as well as the length of the ethylene glycol units (PEGn), since both determine the order of the conjugation reactions and the distance between the linked molecules. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under PEGylation, often used together in one laboratory workflow:

• mPEG (Methyl Polyethylene Glycols)
• Homobifunctional PEG and Oligoethylene Glycols
• PEG Oligomers
• Monofunctional PEG and Oligoethylene Glycols

Back to PEGylation. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official distributor of TCI Japan in Indonesia — for stock availability checks and lead times directly from Japan.