Collection: Homobifunctional Cross-Linkers

Homobifunctional Cross-Linkers — includes cross-linking compounds with two identical reactive groups at both ends of the chain, such as maleimide, hydrazide, or strained alkyne groups, connected by spacer chains such as oligo(ethylene glycol).

Used by biochemistry and bioconjugation researchers to link two biological molecules, such as proteins, peptides, or tracer tags, through reactions with thiol or amine groups, including click-chemistry-based linking without metal catalysts using strained alkyne groups in the construction of protein-protein or protein-label conjugates.

Example products in this collection: TCI A0170 1071-93-8 Adipic Dihydrazide, TCI B5667 115597-84-7 1,8-Bis(maleimido)-3,6-dioxaoctane, TCI T4190 139112-38-2 TMEA, TCI B5668 86099-06-1 1,11-Bis(maleimido)-3,6,9-trioxaundecane, TCI T3241 53397-65-2 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctene, TCI B5683 127828-22-2 N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine, TCI T3198 68960-97-4 1,14-Diamino-3,6,9,12-tetraoxatetradecane, TCI B5699 71865-37-7 Bis(2-maleimidoethyl) Disulfide.

Pay attention to the length of the spacer chain, which determines the distance between linked molecules, the type of reactive groups at both ends such as maleimide, disulfide, or hydrazide, and solubility in aqueous or organic reaction media. All products are genuine products of Tokyo Chemical Industry (TCI) Japan, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Linkers and Crosslinkers, often used together in a single laboratory workflow:

• Heterobifunctional Cross-Linkers
• Photo-reactive Crosslinkers
• Staudinger Ligation

Back to Linkers and Crosslinkers. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for stock availability checks and lead times directly from Japan.