Collection: Linkers and Crosslinkers

Linkers and Crosslinkers — a collection of heterobifunctional and homobifunctional linker and crosslinker molecules, including photoreactive reagents and reagents for Staudinger ligation. These materials carry two or more reactive groups, such as NHS esters, maleimides, and PEG spacers, enabling directed linking between molecules.

Linkers and crosslinkers are used by chemical biology and bioconjugation researchers to connect proteins, peptides, or small molecules to other carriers, for example through NHS ester reactions with amines and maleimide reactions with thiol groups. Photoreactive reagents are used for light-induced crosslinking to study protein interactions, while Staudinger ligation reagents are used in bioorthogonal conjugation strategies.

Example products in this collection: TCI A0170 1071-93-8 Adipic Dihydrazide, TCI B5586 252881-74-6 Amino-PEG3-acid tert-Butyl Ester, TCI U0144 125559-00-4 N-Succinimidyl 6-[[4-(N-Maleimidomethyl)cyclohexyl]carboxamido]hexanoate (2mg*5), TCI B5587 186020-66-6 tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, TCI U0143 64987-85-5 N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (2mg*5), TCI B5651 882847-13-4 21-[(tert-Butoxycarbonyl)amino]-4,7,10,13,16,19-hexaoxaheneicosanoic Acid, TCI U0124 211236-68-9 Sulfo-KMUS, TCI B5665 756525-91-4 (Boc-amino)-PEG4-carboxylic Acid.

Consider the spacer length (e.g., PEG chains), the type of reactive group at each end of the molecule, and the stability of protecting groups such as Boc before selecting a linker that suits the target biomolecule pair. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Chemical Biology, often used together in a single laboratory workflow:

• Peptide Chemistry
• Glycoscience
• Conjugation Chemistry/Click Chemistry
• Bioconjugation
• Nucleic Acid Chemistry
• PEGylation

This collection is further divided into 4 more specific groups:

• Heterobifunctional Cross-Linkers
• Homobifunctional Cross-Linkers
• Photo-reactive Crosslinkers
• Staudinger Ligation

Back to Chemical Biology. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.