Collection: Nucleic Acid Chemistry

Nucleic Acid Chemistry — brings together reagents for nucleic acid synthesis, including coupling activators, nucleoside phosphoramidites, PNA monomers, phosphorylating agents, hydroxy and amino protecting groups, and sulfur transfer reagents. This group presents supporting materials for each stage of oligonucleotide chain assembly chemically.

These reagents are used by chemical biology researchers to synthesize oligonucleotides and their analogs via the phosphoramidite method, including the coupling activation step, installation of protecting groups such as dimethoxytrityl, and modification of phosphate into phosphorothioate. Derivatives such as hexyl and dodecyl phosphoramidites are used to insert functional linkers at the ends of synthetic oligonucleotide chains in molecular biology laboratories.

Examples of products in this collection: TCI D0059 533-67-5 2-Deoxy-D-ribose, TCI B6329 50847-09-1 2-Bromo-1H-imidazole-4,5-dicarbonitrile, TCI A0082 75-36-5 Acetyl Chloride, TCI B6330 99257-95-1 1H-Benzimidazol-3-ium Trifluoromethanesulfonate, TCI X0008 146-80-5 Xanthosine Dihydrate, TCI B6655 158041-82-8 6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl 2-Cyanoethyl N,N-Bis(1-methylethyl)phosphoramidite, TCI X0001 6846-35-1 Xanthane Hydride, TCI B6656 158665-27-1 12-[Bis(4-methoxyphenyl)(phenyl)methoxy]dodecyl 2-Cyanoethyl N,N-Diisopropylphosphoramidite.

Pay attention to phosphoramidite purity, stability against moisture, and the compatibility of protecting groups with the deprotection strategy planned in the synthesis cycle. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Chemical Biology, often used together in one laboratory workflow:

• Peptide Chemistry
• Glycoscience
• Conjugation Chemistry/Click Chemistry
• Bioconjugation
• Linkers and Crosslinkers
• PEGylation

This collection is further divided into 6 more specific groups:

• Phosphorylating Agents and Phosphorothioating Agents [Nucleic Acid Synthesis]
• Coupling Activators and Condensing Agents [Nucleic Acid Synthesis]
• Protecting Agents for Hydroxy and Amino Groups [Nucleic Acid Synthesis]
• Nucleoside Phosphoramidites [Nucleic Acid Synthesis]
• Peptide Nucleic Acid (PNA) Monomers
• Sulfur Transfer Reagents [Nucleic Acid Synthesis]

Back to Chemical Biology. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.