Collection: Protecting Agents for Hydroxy and Amino Groups [Nucleic Acid Synthesis]

Protecting Agents for Hydroxy and Amino Groups [Nucleic Acid Synthesis] — contains silyl chlorides, acyl chlorides, and other protecting compounds used to protect hydroxyl or amino groups on nucleosides before the oligonucleotide synthesis step. These protecting groups are temporary and can be selectively removed again under specific reaction conditions without damaging other parts of the molecule.

Reagents in this category are used in the early stages of oligonucleotide synthesis to install temporary protecting groups, such as tert-butyldimethylsilyl groups on the 2'/5' hydroxyls or acyl groups on the amino groups of nucleobases, before the phosphoramidite coupling step. Nucleic acid chemists choose mutually orthogonal combinations of protecting groups so they can be removed stepwise and selectively without affecting other functional groups on the oligonucleotide chain.

Sample products in this collection: TCI A0082 75-36-5 Acetyl Chloride, TCI C0306 75-77-4 Chlorotrimethylsilane, TCI B1223 58479-61-1 tert-Butyldiphenylchlorosilane, TCI C0308 76-83-5 Trityl Chloride, TCI B1151 57842-27-0 1,3-Benzodithiolylium Tetrafluoroborate [Hydroxyl-Protecting Agent], TCI C0832 4122-68-3 4-Chlorophenoxyacetyl Chloride, TCI B0995 18162-48-6 tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent], TCI D1293 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal.

Pay attention to the types of protecting groups compatible with a stepwise deprotection strategy, the purity of chlorosilane or acid chloride reagents that are sensitive to moisture, and packaging that is watertight and protected from humid vapor. All products are genuine products of Tokyo Chemical Industry (TCI) Japan, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Nucleic Acid Chemistry, often used together in a single laboratory workflow:

• Phosphorylating Agents and Phosphorothioating Agents [Nucleic Acid Synthesis]
• Coupling Activators and Condensing Agents [Nucleic Acid Synthesis]
• Nucleoside Phosphoramidites [Nucleic Acid Synthesis]
• Peptide Nucleic Acid (PNA) Monomers
• Sulfur Transfer Reagents [Nucleic Acid Synthesis]

Back to Nucleic Acid Chemistry. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for stock availability and lead time checks directly from Japan.