4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent] TCI D1612

Chemical Identity

Other names: DMT-Cl · DMT-Cl
CAS No.: 40615-36-9
PubChem: CID 96831·SID 87568093
Formula: C21H19ClO2
Molecular weight: 338.83 g/mol
Purity: >97.0%(HPLC)(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1-[chloro-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene
SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)Cl
InChIKey: JBWYRBLDOOOJEU-UHFFFAOYSA-N
MDL: MDL00008409

Rp 1.035.300,00

~~Rp 723.450,00~~ Rp 1.035.300,00

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4,4'-Dimethoxytrityl Chloride (DMTr-Cl) is a chemical compound widely used as a hydroxyl protecting agent in nucleic acid chemistry. It plays a critical role in the synthesis of nucleotides and nucleic acid molecules by safeguarding hydroxyl groups from unwanted reactions. This compound is essential in biochemical and chemical laboratories, particularly in DNA and RNA research. Its ability to selectively protect hydroxyl groups ensures the accuracy and integrity of molecular structures during complex chemical processes.

DMTr-Cl is valued for its chemical stability and controlled reactivity, making it a reliable choice for protecting functional groups in synthetic reactions. It dissolves easily in organic solvents such as chloroform and DMSO, which simplifies its use in various laboratory applications. The solid form of the compound allows for convenient handling and storage, while its specificity in binding to hydroxyl groups enhances its effectiveness in protecting sensitive molecular structures. These properties make it a preferred reagent in advanced chemical and biochemical experiments.

In Indonesian laboratories, DMTr-Cl is commonly used in biochemistry research, especially in nucleotide synthesis, DNA modification, and drug development. Its reliability and effectiveness in protecting hydroxyl groups make it an essential tool for researchers working on nucleic acid-related projects. The compound is widely available and trusted for its consistent performance in laboratory settings, supporting high-quality scientific research and development.

TCI brochures (PDF)

Nucleic Acid Medicine Synthesis Research Reagents 2024-11-07 · p. 2
Protecting Agents 2025-03-25 · p. 9
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents 2026-03-23 · p. 13

Related TCI products

Nucleotide Synthesis: DMTr-Cl is ideal for protecting hydroxyl groups during the synthesis of nucleotides, ensuring accurate molecular structures.
DNA Modification: It is used to selectively protect hydroxyl groups in DNA molecules, facilitating precise modifications and functional studies.
RNA Research: The compound supports RNA synthesis and modification by preventing unwanted reactions at hydroxyl sites.
Drug Development: DMTr-Cl is employed in the synthesis of nucleotide-based drugs, ensuring stability and specificity in molecular structures.
Organic Chemistry Reactions: Its controlled reactivity and solubility in organic solvents make it suitable for various synthetic reactions requiring hydroxyl protection.

Brand	TCI
CAS number	40615-36-9
Molecular formula	—
Purity	—
Category	Chemistry > Chemical Biology > Nucleic Acid Chemistry
Pack sizes	Available in various quantities as per standard laboratory supply
Physical form	Solid
Storage	Store in a cool, dry place away from moisture and light

DMTr-Cl should be stored in a cool, dry environment to maintain its chemical stability. It is recommended to keep the compound in a tightly sealed container to prevent exposure to moisture and air. Avoid direct sunlight and high humidity to ensure the integrity of the material. When handling, use appropriate personal protective equipment such as gloves and safety goggles to minimize exposure. The compound is non-toxic in normal handling conditions but should be treated with care in laboratory settings. Proper storage and handling practices help maintain the effectiveness and safety of the reagent in research applications.

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