• 143112-49-6 (R)-(-)-DBD-APy [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] - AMI Scientific
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TCI

CAS 143112-49-6

(R)-(-)-DBD-APy [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5561

(R)-(-)-DBD-APy [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5561

Chemical Identity

Other names
(R)-(-)-DBD-APy
CAS No.
143112-49-6
PubChem
CID 15682838·SID 87563178
Formula
C12H17N5O3S
Molecular weight
311.36 g/mol
Purity
>98.0%(HPLC)
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
7-[(3R)-3-aminopyrrolidin-1-yl]-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide
SMILES
CN(C)S(=O)(=O)C1=CC=C(C2=NON=C12)N3CC[C@H](C3)N
InChIKey
SZJGHUNJZRXXCA-MRVPVSSYSA-N
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(R)-(-)-DBD-APy is a derivatization reagent used in analytical chemistry for the determination of enantiomeric excess (e.e.) in optically active compounds. This reagent plays a crucial role in laboratories where high-resolution analysis of chiral substances is required. It is specifically designed to label chiral compounds, enabling their detection and quantification through high-performance liquid chromatography (HPLC). Its application is vital in fields such as pharmacology, organic chemistry, and the analysis of complex chemical mixtures.

The chemical properties of (R)-(-)-DBD-APy make it a preferred choice for analytical applications. It exhibits chemical stability and good reactivity toward target compounds, ensuring reliable results. The molecular structure is engineered to form stable complexes with optically active substances, facilitating accurate detection and separation in chromatographic analysis. Its compatibility with HPLC systems and ability to enhance resolution make it an essential tool for laboratories requiring precise enantiomeric analysis.

In Indonesian laboratories, (R)-(-)-DBD-APy is commonly used in pharmaceutical research and development, industrial chemical analysis, and studies of bioactive compounds. Its availability in solid form simplifies storage and handling, making it a practical choice for routine analytical procedures. Researchers rely on this reagent to obtain accurate and reproducible data, supporting advancements in drug discovery and chemical analysis.

Advantages (TCI brochure)

  • Optically active reagent used for optical purity determination of carboxylic acids
  • Mild labeling (Mukaiyama-Corey method) produces diastereomers without racemization
  • Diastereomers separated by reversed phase HPLC; highly sensitive peroxyoxalate CL detection possible

TCI brochures (PDF)

Related TCI products

  • Pharmaceutical research and development where enantiomeric purity of drug compounds is critical for ensuring therapeutic efficacy and safety.
  • Industrial chemical analysis to assess the optical purity of chiral compounds used in manufacturing processes.
  • Bioactive compound studies to evaluate the enantiomeric composition of substances with biological activity.
  • Quality control in the production of chiral pharmaceuticals to meet regulatory standards and ensure product consistency.
  • Academic research in organic chemistry and analytical sciences for the study of chiral molecules and their behavior in different environments.

From the TCI brochure

  • Optical purity determination of chiral carboxylic acids (naproxen, ibuprofen)

Brand TCI
CAS number 143112-49-6
Molecular formula —
Purity —
Category Analytical Chemistry > Analytical Reagents > Derivatization Reagents
Pack sizes —
Physical form Solid
Storage Store in a cool, dry place away from light

Data from the TCI brochure

Excitation wavelength470 nm (Fluorescence detection)
Emission wavelength580 nm (Fluorescence detection)
Detection limit (S/N = 2)10 fmol (Naproxen)
Mobile phaseCH3CN / H2O = 50 / 50 (naproxen); CH3CN / H2O = 60 / 40 (ibuprofen) (40 C, Kaseisorb LC ODS Super, 1 mL/min)

Source: TCI brochure A1096 (2026-03-10)

This reagent should be stored in a cool, dry place, away from direct light and sources of heat to maintain its chemical stability. It is recommended to use airtight containers to prevent moisture absorption and contamination. Due to its chemical nature, it should be handled with care, using appropriate personal protective equipment such as gloves and safety goggles. Avoid exposure to incompatible substances and ensure proper ventilation in the laboratory. The reagent is not flammable or explosive, but general laboratory safety protocols should be followed when working with chemical reagents. Proper labeling and storage conditions are essential to ensure the integrity and usability of the material over time.

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Analytical Chemistry

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