• 143112-52-1 (S)-(+)-NBD-APy [=(S)-(+)-4-Nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] - AMI Scientific
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TCI

CAS 143112-52-1

(S)-(+)-NBD-APy [=(S)-(+)-4-Nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5562

(S)-(+)-NBD-APy [=(S)-(+)-4-Nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5562

Chemical Identity

Other names
(S)-(+)-NBD-APy
CAS No.
143112-52-1
PubChem
CID 15682841·SID 87563179
Formula
C10H11N5O3
Molecular weight
249.23 g/mol
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
(3S)-1-(4-nitro-2,1,3-benzoxadiazol-7-yl)pyrrolidin-3-amine
SMILES
C1CN(C[C@H]1N)C2=CC=C(C3=NON=C23)[N+](=O)[O-]
InChIKey
QSDDQXROWUJAJX-LURJTMIESA-N
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(S)-(+)-NBD-APy is a specialized chemical reagent used in quantitative analysis to determine the enantiomeric excess (e.e.) of a compound. It functions as a labeling agent in derivatization processes, enabling the detection and separation of enantiomers through high-performance liquid chromatography (HPLC). This reagent plays a critical role in analytical chemistry, particularly in the study of optically active compounds such as pharmaceuticals, chemical intermediates, and industrial materials. Its application is essential for ensuring the accuracy and reliability of enantiomeric analysis in both research and quality control settings.

The key properties that make (S)-(+)-NBD-APy a preferred choice include its high specificity for target compounds and its ability to produce distinct chromatographic responses. It exhibits excellent stability under standard laboratory conditions, ensuring consistent performance over time. Additionally, its chemical structure allows for efficient derivatization, enhancing the sensitivity and selectivity of HPLC analysis. These characteristics make it a reliable tool for researchers aiming to achieve precise and reproducible results in enantiomeric studies.

In Indonesian laboratories, (S)-(+)-NBD-APy is commonly used in analytical chemistry research, particularly in academic institutions and research centers. It supports the analysis of optically active compounds, contributing to the development of pharmaceuticals and industrial chemicals. Its presence in Indonesian laboratories reflects the growing demand for advanced analytical tools to meet international standards in compound analysis.

Advantages (TCI brochure)

  • Optically active reagent used for optical purity determination of carboxylic acids
  • Mild labeling produces diastereomers without racemization
  • Diastereomers separated by reversed phase HPLC; highly sensitive detection with laser induced fluorescence detector

TCI brochures (PDF)

Related TCI products

  • Enantiomeric Excess Determination: This reagent is ideal for measuring the e.e. of chiral compounds, providing accurate data for pharmaceutical and chemical research.
  • Pharmaceutical Analysis: It supports the analysis of optically active drug substances, aiding in quality control and formulation development.
  • HPLC Derivatization: Its ability to label chiral compounds makes it suitable for HPLC-based separation and detection of enantiomers.
  • Industrial Chemical Testing: It is used to analyze optically active intermediates in the production of chemical products.
  • Academic Research: It is widely applied in university laboratories for teaching and research in analytical chemistry and chiral analysis.

From the TCI brochure

  • Optical purity determination of chiral carboxylic acids (naproxen, ibuprofen)

Brand TCI
CAS number 143112-52-1
Molecular formula —
Purity —
Category Analytical Chemistry > Analytical Reagents > Derivatization Reagents
Pack sizes Available in various quantities as per supplier specifications
Physical form Solid or liquid, depending on the specific product variant
Storage Store in a cool, dry place away from direct light

Data from the TCI brochure

Excitation wavelength470 nm (Fluorescence detection)
Emission wavelength540 nm (Fluorescence detection)
Detection limit (S/N = 2)15 fmol (Naproxen)
Mobile phaseCH3CN / H2O = 50 / 50 (naproxen); CH3CN / H2O = 60 / 40 (ibuprofen) (40 C, Kaseisorb LC ODS Super, 1 mL/min)

Source: TCI brochure A1096 (2026-03-10)

(S)-(+)-NBD-APy should be stored in a cool, dry environment to maintain its stability and effectiveness. It is recommended to keep the reagent in a tightly sealed container to prevent moisture absorption and contamination. Avoid exposure to direct sunlight or high temperatures, as these can degrade the chemical properties of the reagent. In a laboratory setting, always handle the reagent with appropriate personal protective equipment, such as gloves and safety goggles. Ensure that the storage area is well-ventilated to minimize any potential inhalation risks. Regularly check the reagent's condition to ensure it remains suitable for use in analytical procedures.

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