TCI B6396, 3-acetylbiphenyl (CAS 3112-01-4), is an aromatic methyl ketone that combines a rigid biphenyl framework with a versatile acetyl handle at the meta position. The ketone readily undergoes reduction, Grignard addition, aldol and Claisen-Schmidt condensations, and condensation with binucleophiles to give pyrazoles, isoxazoles, and related heterocycles. α-Halogenation of the acetyl group also provides access to reactive phenacyl halides for further alkylation chemistry. Supplied as a 1 g pack, this solid should be kept tightly closed in a cool, dry place, protected from light and away from strong oxidisers.
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- Bi et al. (1996). Synthesis and Antibacterial Activity of Copper(Ⅱ) Acetylbiphenyl Thiosemicarbazone Complex. Chinese Journal of Applied Chemistry doi:10.3724/j.issn.1000-0518.1996.2.1517
- Zobač dkk. (2020). Directionality in van der Waals Interactions: The Case of 4-Acetylbiphenyl Adsorbed on Au(111). The Journal of Physical Chemistry C doi:10.1021/acs.jpcc.9b09599
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