TCI B6400, tert-butyl (R)-2-methylpiperazine-1-carboxylate (CAS 170033-47-3), is a mono-Boc-protected chiral piperazine building block with defined (R) configuration at C-2. The selective protection leaves the N-4 nitrogen free for alkylation, acylation, sulfonylation, reductive amination, or Buchwald–Hartwig coupling. Subsequent acid-mediated Boc removal unmasks the second nitrogen for further elaboration, making the reagent well suited to multi-step medicinal chemistry routes. AMI Scientific supplies it in 1 g and 5 g packs; refer to the lot Certificate of Analysis for stereochemical and purity data.
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- STUDER et al. (1995). ChemInform Abstract: Synthesis and First Applications of a New Chiral Auxiliary (tert‐Butyl 2‐(tert‐Butyl)‐5,5‐dimethyl‐4‐oxoimidazolidine‐1‐carboxylate) (V).. ChemInform doi:10.1002/chin.199547157
- Mamat et al. (2012). Synthesis and Molecular Structure of tert-Butyl 4-(2-tert-butoxy-2-oxoethyl)piperazine-1-carboxylate. Crystals doi:10.3390/cryst2010090
- Grauer et al. (2009). Synthesis of rac-tert-butyl 3-(benzyloxycarbonylamino)-2-(4-bromophenyl)-tetrahydrofuran-3-carboxylate. Molbank doi:10.3390/m596
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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