TCI
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Description
TCI C0291 N-Chlorosuccinimide (NCS, CAS 128-09-6) is a classic solid source of electrophilic chlorine that is far easier to weigh and handle than chlorine gas. It is routinely used for allylic and benzylic chlorination, alpha-chlorination of carbonyl compounds, and selective chlorination of electron-rich aromatics. NCS also drives controlled oxidations of alcohols to aldehydes and ketones, most notably in the Corey–Kim protocol with dimethyl sulfide. AMI Scientific supplies this TCI reagent in 25 g, 100 g, and 500 g packs; as an oxidising and corrosive solid, it should be kept cool, dry, and well away from reducing agents and combustible materials.
Scientific References
- Chauhan (2010). N-Chlorosuccinimide (NCS). Synlett doi:10.1055/s-0029-1219581
- Dim et al. (2024). Ka-Band Rotational Spectroscopy of Succinimide and N-Chlorosuccinimide. The Journal of Physical Chemistry A doi:10.1021/acs.jpca.4c06004
- (2006). N-Chlorosuccinimide. Cold Spring Harbor Protocols doi:10.1101/pdb.caut256
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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