TCI C0421 Croton Oil (CAS 8001-28-3) is a plant-derived oil widely applied in the preparation of animal disease models. Its phorbol ester content produces a rapid and reproducible inflammatory response, making it a common positive control in anti-inflammatory drug screening. The material is also used in two-stage skin carcinogenesis studies and in research on protein kinase C-mediated signalling. Because it is strongly irritant, all handling should take place in a fume hood with full personal protective equipment and in accordance with the manufacturer's safety data sheet.
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- BENSIMON (2008). Croton oil peels. Aesthetic Surgery Journal doi:10.1016/j.asj.2007.10.005
- BENSIMON (2008). Croton Oil Peels. Aesthetic Surgery Journal doi:10.1016/j.asj.2008.05.005
- KOTLER (2008). Croton Oil Peels. Aesthetic Surgery Journal doi:10.1016/j.asj.2008.05.003
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