TCI C0437 2-Cyanoacetamide (CAS 107-91-5) is a classic active methylene building block containing both nitrile and amide groups. Its acidic methylene protons make it highly reactive toward aldehydes and ketones in Knoevenagel condensations. The resulting adducts are widely cyclised into pyridone, pyrimidine, and pyran heterocycles used in medicinal chemistry and dye research. The crystalline solid should be kept tightly sealed in a cool, dry place and handled with gloves and eye protection in a well-ventilated area.
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- Zdzienicka (2013). 2-Cyanoacetamide. Synlett doi:10.1055/s-0033-1338942
- (2014). Four - Component Reaction Between Cyanoacetamide, Aryl Aldehydes and Ethyl Acetoacetate with Ammonium Acetate. Chemical Science Transactions doi:10.7598/cst2014.204
- Zakhari (1990). Spectrophotometric Assay of Certain Aminoglycosides Using Cyanoacetamide. Analytical Letters doi:10.1080/00032719008052531
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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