2-Chlorophenyl Phosphorodichloridate [Phosphorylating Agent] TCI C0976

Chemical Identity

Other names: 2-Chlorophenylphosphoryl Dichloride
CAS No.: 15074-54-1
PubChem: CID 84775·SID 87566021
Formula: C6H4Cl3O2P
Molecular weight: 245.42 g/mol
Purity: >97.0%(T)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1-chloro-2-dichlorophosphoryloxybenzene
SMILES: C1=CC=C(C(=C1)OP(=O)(Cl)Cl)Cl
InChIKey: VLDPXPPHXDGHEW-UHFFFAOYSA-N
MDL: MDL00009704

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2-Chlorophenyl Phosphorodichloridate is a phosphorylating agent supplied by TCI. Chemists use it to introduce a phosphate group into organic molecules. Its structure has a phosphorus atom bonded to a 2-chlorophenoxy group and two reactive chlorine atoms. The reagent is widely known in synthetic chemistry laboratories for preparing phosphate esters. It is also used in the phosphotriester method, where it forms internucleotide linkages during oligonucleotide synthesis. This makes it an important tool for researchers in bioorganic chemistry and nucleic acid chemistry who need a reliable way to build phosphorus-containing structures.

The reagent's main advantage is the two chlorine atoms on phosphorus. They can react one at a time with two different nucleophiles, such as two separate hydroxyl groups. This allows phosphate diester linkages to be formed in a controlled order rather than all at once. The 2-chlorophenyl group protects the phosphorus atom while the synthesis proceeds and can be removed later under suitable conditions. High reactivity combined with a removable protecting group is why chemists choose this reagent to assemble phosphate-bearing molecules systematically. Because it is highly sensitive to moisture, it needs careful handling to keep that reactivity.

In Indonesia, phosphorylating reagents like this one are relevant to synthetic organic chemistry laboratories at universities, research institutes, and industrial research and development groups. Researchers working on phosphate esters, nucleotide chemistry, or oligonucleotide assembly can use it in multistep synthesis programs. It also suits teaching and research groups that study phosphorus chemistry and protecting-group strategies. AMI Scientific supplies this TCI reagent to laboratories that need a well-characterised building block for phosphorylation work as part of their routine or exploratory synthesis.

TCI brochures (PDF)

Nucleosides, Nucleotides, Nucleic Acids and Related Reagents 2026-03-23 · p. 14

Related TCI products

Phosphate ester synthesis: the reactive phosphorus–chlorine bonds let chemists attach a phosphate group to organic alcohols, which makes this reagent a direct route to phosphate esters.
Oligonucleotide synthesis by the phosphotriester method: the reagent is well known for forming internucleotide bonds, which supports the stepwise assembly of nucleotide chains in nucleic acid research.
Stepwise coupling of two different nucleophiles: the two chlorine atoms react one after the other, so two distinct hydroxyl-bearing molecules can be joined through a controlled phosphate diester linkage.
Protecting-group strategies in phosphorus chemistry: the 2-chlorophenyl group protects the phosphorus atom during synthesis and can be removed later, which suits multistep routes that need temporary protection.
Bioorganic chemistry research: groups studying phosphorylated biomolecules can use this reagent to build phosphate-containing structures systematically, combining high reactivity with a protecting group that can be removed later.

Brand	TCI (product code C0976)
CAS number	15074-54-1
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	See the available options on the product listing
Physical form	—
Storage	Highly sensitive to moisture; keep tightly sealed under dry conditions

Reagent type: Phosphorylating agent

2-Chlorophenyl Phosphorodichloridate is highly sensitive to moisture, so keep it away from humidity and water at all times. Store it in its original, tightly closed container in a cool, dry, well-ventilated area, preferably under a dry inert atmosphere once opened. Reseal the container promptly after each use to limit exposure to air. Handle the reagent in a fume hood and use dry glassware and equipment. Wear suitable personal protective equipment, including chemical-resistant gloves, safety goggles, and a laboratory coat. Keep it apart from incompatible materials, and always read the supplier's Safety Data Sheet before use for full hazard, handling, and disposal information.

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