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TCI

CAS 5381-99-7

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one TCI C1210

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one TCI C1210

Chemical Identity

Other names
Salicylchlorophosphite · Van Boom's Reagent
CAS No.
5381-99-7
PubChem
CID 237010·SID 87566233
Formula
C7H4ClO3P
Molecular weight
202.53 g/mol
Purity
>95.0%(T)
Storage
0-10°C
Reference databases
ECHA
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
2-chloro-1,3,2-benzodioxaphosphinin-4-one
SMILES
C1=CC=C2C(=C1)C(=O)OP(O2)Cl
InChIKey
BVOITXUNGDUXRW-UHFFFAOYSA-N
MDL
MDL00013353
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TCI C1210 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, CAS 5381-99-7, is a cyclic phosphorus(III) chloride reagent widely used for phosphitylation of free hydroxyl groups. It reacts readily with nucleosides, sugars, and other alcohols to give phosphorus(III) intermediates that can subsequently be oxidised, sulfurised, or cyclised. Because of this, it is a standard tool in nucleotide chemistry, cyclic phosphate synthesis, and phosphorus-containing prodrug research. AMI Scientific supplies 5 g and 25 g packs; the reagent is highly moisture sensitive and must be handled under dry, inert conditions in line with the manufacturer's Safety Data Sheet.

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