TCI C1210 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, CAS 5381-99-7, is a cyclic phosphorus(III) chloride reagent widely used for phosphitylation of free hydroxyl groups. It reacts readily with nucleosides, sugars, and other alcohols to give phosphorus(III) intermediates that can subsequently be oxidised, sulfurised, or cyclised. Because of this, it is a standard tool in nucleotide chemistry, cyclic phosphate synthesis, and phosphorus-containing prodrug research. AMI Scientific supplies 5 g and 25 g packs; the reagent is highly moisture sensitive and must be handled under dry, inert conditions in line with the manufacturer's Safety Data Sheet.
TCI brochures (PDF)
- Nucleosides, Nucleotides, Nucleic Acids and Related Reagents 2026-03-23 · p. 14
Related TCI products
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Product Categories
- Building BlocksNon-Heterocyclic Building BlocksPhosphorus Compounds [Non-Heterocyclic Building Blocks]
- Catalysis and Inorganic ChemistryPhosphorous Compounds [Catalysis and Inorganic Chemistry]Phosphorus Precursors [Catalysis]
- Chemical BiologyNucleic Acid ChemistryPhosphorylating Agents and Phosphorothioating Agents [Nucleic Acid Synthesis]
- Synthetic ReagentsC-X(Non-Halogen) Bond Formation [Synthetic Reagents]Phosphorylation [Synthetic Reagents]
- Pharmaceutical Development and Drug Discovery Research ReagentsNucleic Acid ChemistryPhosphorylating Agents and Phosphorothioating Agents [Nucleic Acid Synthesis]



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