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Description
TCI C1035 Cyclobutyl Phenyl Ketone (CAS 5407-98-7) is an aryl cycloalkyl ketone that introduces the conformationally rigid cyclobutane motif into target molecules. The carbonyl group readily undergoes organometallic addition, reduction to the secondary alcohol, reductive amination, and oxime or hydrazone formation. Cyclobutyl groups are frequently explored as bioisosteres in modern medicinal chemistry, making this a useful exploratory building block. AMI Scientific supplies it in a 5 g research pack; dispense in a fume hood with appropriate protection and consult the official TCI Safety Data Sheet.
Scientific References
Fitjer (1995). Cyclobutyl phenyl sulfoxide and (SR)-cyclobutyl p-tolyl sulfoxide: new reagents for the spiroannelation of cyclopentanone. Tetrahedron Lettersdoi:10.1016/00404-0399(50)0958f-
Fitjer et al. (1995). Cyclobutyl phenyl sulfoxide and (SR)-cyclobutyl p-tolyl sulfoxide: New reagents for the spiroannelation of cyclopentanone. Tetrahedron Lettersdoi:10.1016/0040-4039(95)00958-f
FITJER et al. (1995). ChemInform Abstract: Cyclobutyl Phenyl Sulfoxide and (SR)‐Cyclobutyl p‐Tolyl Sulfoxide: New Reagents for the Spiroanellation of Cyclopentanone.. ChemInformdoi:10.1002/chin.199542091
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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