TCI C1059 Cyclopropanecarbonyl Chloride, CAS 4023-34-1, is a reactive acid chloride used to introduce the cyclopropanecarbonyl group into amides, esters, and aromatic substrates. The cyclopropane motif is frequently sought in medicinal chemistry for the conformational rigidity it adds to a molecule. AMI Scientific offers this TCI reagent in 25 g and 500 g pack sizes for both trial reactions and repeated preparative work. It is corrosive and readily hydrolysed, so handle it in a fume hood with dry glassware and follow the official TCI Safety Data Sheet.
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- de Boer et al. (1992). The influence of substituents on the geometry of the cyclopropane ring. VI The molecular and crystal structures of cyclopropanecarboxylic acid and cyclopropanecarbonyl chloride. Recueil des Travaux Chimiques des Pays-Bas doi:10.1002/recl.19921110905
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