Diethyl (2-cyanoethyl)malonate (TCI C1153, CAS 17216-62-5) is a bifunctional building block that combines an active malonate methylene with a terminal nitrile side chain. This arrangement lets researchers alkylate the malonate core while reserving the nitrile for later conversion into amines, amides, or carboxylic acids. It is widely used in the construction of nitrogen heterocycles, lactam frameworks, and non-natural amino acid analogues during early-stage synthetic work. Supplied in a 25 g research pack, it should be handled in a fume hood and stored in a tightly closed container following the manufacturer's label and SDS.
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