TCI C1225 4-Chloro-3-nitroanisole (CAS 10298-80-3) is a trisubstituted aromatic building block bearing methoxy, chloro, and nitro groups on a single benzene ring. The nitro group strongly activates the chlorine toward nucleophilic aromatic substitution, allowing straightforward displacement by amines, alkoxides, and thiolates. Reduction of the nitro group opens a second route toward substituted anilines and downstream heterocyclic scaffolds. AMI Scientific supplies this TCI reagent in a 25 g pack size, and it should be handled in a fume hood with appropriate personal protective equipment.
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