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TCI

CAS 10298-80-3

4-Chloro-3-nitroanisole TCI C1225

4-Chloro-3-nitroanisole TCI C1225

Chemical Identity

Other names
2-Chloro-5-methoxynitrobenzene
CAS No.
10298-80-3
PubChem
CID 25140·SID 87566246
Formula
C7H6ClNO3
Molecular weight
187.58 g/mol
Purity
>98.0%(GC)
Reference databases
ECHA
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
1-chloro-4-methoxy-2-nitrobenzene
SMILES
COC1=CC(=C(C=C1)Cl)[N+](=O)[O-]
InChIKey
HISHUMDTGXICEZ-UHFFFAOYSA-N
MDL
MDL00007077
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TCI C1225 4-Chloro-3-nitroanisole (CAS 10298-80-3) is a trisubstituted aromatic building block bearing methoxy, chloro, and nitro groups on a single benzene ring. The nitro group strongly activates the chlorine toward nucleophilic aromatic substitution, allowing straightforward displacement by amines, alkoxides, and thiolates. Reduction of the nitro group opens a second route toward substituted anilines and downstream heterocyclic scaffolds. AMI Scientific supplies this TCI reagent in a 25 g pack size, and it should be handled in a fume hood with appropriate personal protective equipment.

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