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Description
TCI C1225 4-Chloro-3-nitroanisole (CAS 10298-80-3) is a trisubstituted aromatic building block bearing methoxy, chloro, and nitro groups on a single benzene ring. The nitro group strongly activates the chlorine toward nucleophilic aromatic substitution, allowing straightforward displacement by amines, alkoxides, and thiolates. Reduction of the nitro group opens a second route toward substituted anilines and downstream heterocyclic scaffolds. AMI Scientific supplies this TCI reagent in a 25 g pack size, and it should be handled in a fume hood with appropriate personal protective equipment.
![[[(7-Bromoheptyl)oxy]methyl]benzene (CAS 94427-22-2) - TCI B6162 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6162.jpg?v=1768815997&width=533)