TCI C1319 Methyl 4-Chloro-2-methylbutyrate is a bifunctional aliphatic ester bearing a terminal alkyl chloride and an alpha methyl branch. The chloride serves as a leaving group for alkylating nucleophiles, while the ester can be hydrolysed, reduced, or cyclised into lactams and lactones. Its alpha methyl group also introduces a stereogenic centre relevant to stereochemical studies. AMI Scientific offers this TCI product in 5 g and 25 g packs; handle it in a fume hood and keep the container tightly closed.
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- Ferguson et al. (1997). Mechanism and Stereochemistry of the Reaction of Dichloroplatinum(II) Complexes with Diazo Compounds. X-ray Structures of Four Key Products: [(2R,3R)-Bis(diphenylphosphino)butane]chloro- [(S)-chloro(methoxycarbonyl)methyl]platinum(II), (η4-1,5-Cyclooctadiene)[3-chloro-5-(dimethoxyphosphonyl)-2- methoxy-4,1,2-platinaoxaphospholane P-oxide], (R,R)-[Chloro(dimethoxyphosphonyl)methyl][chloro- (trimethylsilyl)methyl](1,5-cyclooctadiene)platinum(II), and Chloro[chloro(dimethoxyphosphonyl)methyl](η4-1,5-cyclooctadiene)platinum(II). Organometallics doi:10.1021/om9607964
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