4-Cyanophenacyl bromide (CAS 20099-89-2) from TCI is a highly reactive α-bromoketone building block supplied by AMI Scientific. It serves as a classical alkylating reagent and reacts with thioamides and amidines to form thiazole and imidazole rings in a single step. The para-cyano group provides a second handle that can later be converted into amides, amines, acids, or tetrazoles. Because phenacyl bromides are strong lachrymators and irritants, all handling should take place in a fume hood with appropriate personal protective equipment.
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