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Description
TCI C1518 2-Cyanopyrimidine (CAS 14080-23-0) is a heterocyclic building block bearing a nitrile group directly attached to the electron-poor pyrimidine ring. The nitrile provides a direct route to amidines, tetrazoles, amides, and aminomethyl derivatives, while heteroaryl nitriles themselves are studied as mild electrophilic motifs in reversible covalent inhibitor design. The pyrimidine core is one of the most frequently encountered scaffolds in medicinal chemistry, which makes this reagent broadly useful in discovery work. It is available in 1 g, 5 g, and 25 g packs; refer to the TCI Certificate of Analysis and Safety Data Sheet for binding specifications.
Scientific References
Göhring et al. (1996). Development of a Process to Prepare 2-Cyanopyrimidine on Commercial Scale. CHIMIAdoi:10.2533/chimia.1996.538
HU et al. (1995). ChemInform Abstract: A Convenient Direct Preparation of 2‐Cyanopyrimidine.. ChemInformdoi:10.1002/chin.199525158
Hu et al. (1994). A CONVENIENT DIRECT PREPARATION OF 2-CYANOPYRIMIDINE. Organic Preparations and Procedures Internationaldoi:10.1080/00304949409458169
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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