TCI C1547, 4'-Chlorobutyrophenone (CAS 4981-63-9), is an aryl ketone that pairs a para-chlorinated phenyl ring with a butyryl chain. The butyrophenone framework is a familiar motif in medicinal chemistry, while the carbonyl group supports classical transformations such as reduction to the secondary alcohol and reductive amination. The para-chloro substituent provides an additional handle for nucleophilic aromatic substitution and metal-catalysed cross-coupling. Available from AMI Scientific in a 25 g pack, it should be handled in a fume hood and stored tightly closed in a cool, dry place away from heat and strong oxidisers.
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- Anilkumar et al. (2005). 4-tert-Butyl-γ-chlorobutyrophenone. Acta Crystallographica Section E Structure Reports Online doi:10.1107/s1600536805028771
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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