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Description
TCI C2067 is 5-(Carbobenzoxyamino)valeric Acid, a 5-aminovaleric acid whose amino group has been protected with a carbobenzoxy or benzyloxycarbonyl group, commonly abbreviated as Cbz or Z. The compound serves as a ready-to-use protected building block in peptide chemistry and organic synthesis laboratories. Because the protecting group is already installed, researchers can directly activate the carboxyl terminus without concern for cross-reaction at the amine. Its straight, flexible five-carbon chain also makes it a highly useful linker or spacer when designing molecular conjugates.
The principal characteristic of this material is the presence of two clearly differentiated functional termini: one end is a free carboxylic acid that can be coupled to form amides or esters, and the other is a protected amine that can be selectively unmasked again through catalytic hydrogenolysis. This kind of orthogonal strategy gives researchers full control over the order of bond formation, an absolute requirement in stepwise peptide synthesis as well as in the preparation of linker molecules. The Cbz group itself is stable toward mild basic conditions and many common coupling reagents, yet can be removed cleanly when required.
In Indonesian laboratories, this building block is typically used in university and institutional research groups working on peptide chemistry, medicinal chemistry, and organic synthesis, as well as in bioconjugate and linker development programmes. It is handled in standard synthetic chemistry workflows where reagents are weighed out, dissolved in organic solvents, and carried through coupling and deprotection steps. Its predictable reactivity and defined protection scheme make it suitable for both routine teaching-linked research work and more advanced multistep synthesis projects.
Laboratory Applications
Stepwise peptide synthesis — the pre-installed Cbz protection prevents unwanted self-coupling at the amine, allowing the free carboxylic acid to be activated and joined selectively in the intended sequence.
Linker and spacer construction — the straight, flexible five-carbon backbone provides controlled separation between two coupled fragments, which is important when designing molecular conjugates that require spatial freedom.
Bioconjugate preparation — the two distinguishable termini let researchers attach one partner through amide or ester coupling first, then unmask the amine for a second, independent attachment step.
Amide and ester bond formation studies — the free carboxylic acid end couples readily with common coupling reagents, while the protected amine remains untouched, giving clean and interpretable reaction outcomes.
Orthogonal protecting group strategy work — the Cbz group is stable to mild base and many coupling reagents yet removable by catalytic hydrogenolysis, making it a reliable model for teaching and developing selective deprotection sequences.
Specifications
Brand: TCI
CAS number: 23135-50-4
Chemical name: 5-(Carbobenzoxyamino)valeric Acid
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: available in the standard catalogue pack sizes offered for this product code
Storage: store according to the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, moisture, and incompatible materials, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original supplier container or in a clean, chemically compatible and clearly labelled vessel, and reseal it promptly after each use to limit moisture uptake. Handle in a fume hood using appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Avoid inhalation of dust and contact with skin and eyes, weigh out quantities carefully, and dispose of residues and contaminated materials in accordance with institutional chemical waste procedures.
