5-(Carbobenzoxyamino)valeric Acid is an organic building block widely used in chemistry laboratories, particularly in peptide synthesis and stepwise organic synthesis. Chemically, it is a derivative of valeric acid bearing a five-carbon chain with an amino group at position 5, and that amino group is protected by a carbobenzoxy group, commonly abbreviated as Cbz or Z. Its principal role is to deliver the 5-aminovalerate unit, a non-natural amino acid, into a target molecular framework without the risk of side reactions at the amine group, making it an important starting material for pharmaceutical intermediates, peptide assembly, and the development of cross-linked molecules for research.
The TCI-labeled product, catalog number C2067, is chosen by laboratories because of its consistent, tested quality for synthesis that demands high purity. The main strength of this compound lies in its Cbz protecting group, which is stable under a wide range of reaction conditions, including basic environments. This stability allows the carbon chain to be manipulated first, before the amino group is released at the desired stage of the synthesis. The Cbz group can then be removed selectively through hydrogenation, enabling controlled, stepwise construction of the target molecule with minimal risk of unintended side reactions.
In Indonesian laboratories, this building block is typically used in medicinal chemistry research and academic synthesis projects, where it serves as a dependable starting material for pharmaceutical intermediates and peptide assembly. It is also employed in the development of cross-linked molecules for various research purposes. Researchers value its predictable behavior under routine conditions, making it a practical choice for multi-step reaction sequences that require a protected amine to be carried through several transformations before final deprotection.
- Peptide synthesis: The protected amino group allows the 5-aminovalerate unit to be introduced into peptide chains without unwanted side reactions during coupling and elongation steps.
- Pharmaceutical intermediate preparation: This building block provides a reliable route to non-natural amino acid fragments used in the synthesis of drug-like compounds and active pharmaceutical ingredients.
- Stepwise organic synthesis: The Cbz group remains stable through multiple reaction stages, enabling sequential manipulation of the carbon chain before selective deprotection by hydrogenation.
- Cross-linked molecule development: The compound supplies a versatile spacer unit with a masked amine, facilitating the construction of linked or conjugated structures for research applications.
- Medicinal chemistry research: Consistent quality and tested purity make this reagent a dependable starting material for academic and industrial research projects across Indonesia.
| Brand | TCI, catalog number C2067 |
|---|---|
| CAS number | 23135-50-4 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | as listed in the TCI catalog and indicated on the product label |
| Physical form | — |
| Storage | — |
- Product name: 5-(Carbobenzoxyamino)valeric Acid
- Chemical identity: a valeric acid derivative carrying a Cbz-protected amino group at position 5
Store the product in a tightly sealed container in a cool, dry place, protected from moisture and direct sunlight, following the storage conditions indicated on the label. Keep the bottle closed when not in use and use containers made of suitable laboratory materials. When handling, wear appropriate personal protective equipment such as gloves and safety glasses, and work in a well-ventilated area or fume hood. Avoid inhalation of dust and contact with skin or eyes, and keep the reagent away from incompatible substances. Observe standard laboratory hygiene, including washing hands after handling, and dispose of any waste in accordance with applicable laboratory regulations.
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