Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Description
TCI C3052 3-Chloro-5-fluoroaniline is a substituted aniline compound carrying one chlorine atom and one fluorine atom positioned meta to the aromatic amine group. It belongs to the class of fluorinated building blocks, high-value starting materials used by synthetic chemists to construct more complex target molecules. Its aromatic amine group is readily transformed through a range of classical reactions such as acylation, sulfonylation, diazonium salt formation, and amidation, making this compound a flexible starting point for designing new molecular frameworks in the organic chemistry laboratory.
The characteristic that makes this material attractive lies in its halogen substitution pattern. The fluorine atom imparts a distinctive electronic influence, improving metabolic stability and affecting the lipophilic properties of derivative molecules — an important consideration in medicinal chemistry and agrochemical research. The chlorine atom, meanwhile, serves as a synthetic handle that can either be retained as a permanent substituent or exploited in transition metal-catalysed cross-coupling reactions. The combination of two different halogens on a single ring gives researchers useful control over selectivity when designing multi-step routes.
In Indonesian laboratories, this building block is typically used in university research groups, organic synthesis teaching laboratories, and industrial R&D units working on pharmaceutical intermediates and agrochemical candidates. It is normally handled at bench scale within a fume hood, weighed out for small-scale reaction screening, and stored alongside other halogenated aromatic intermediates in a dedicated chemical inventory. Supplied under the TCI brand, it fits into workflows where consistent, well-characterised reagents are needed for reproducible synthetic work.
Laboratory Applications
- Pharmaceutical intermediate synthesis — the reactive aromatic amine allows straightforward acylation and amidation steps that build the amide linkages commonly found in drug candidate scaffolds.
- Cross-coupling chemistry — the chlorine substituent acts as a synthetic handle for transition metal-catalysed carbon–carbon and carbon–nitrogen bond formation in multi-step route development.
- Agrochemical research — the fluorine atom modulates lipophilicity and metabolic stability, properties frequently targeted when developing new crop protection active ingredients.
- Diazonium salt chemistry — the aromatic amine is readily converted to a diazonium intermediate, opening access to further functional group interconversions on the halogenated ring.
- Fluorinated scaffold development — the dual-halogen substitution pattern gives synthetic chemists selectivity control when assembling novel molecular frameworks from a single starting material.
Specifications
- Brand: TCI
- CAS number: 4863-91-6
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: C3052
- Pack sizes: available in standard TCI research-scale packaging; please confirm the required size when ordering
- Storage: keep in a cool, dry place in the tightly closed original container
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents and strong acids. The original supplier container is the most suitable packaging; if transfer is necessary, use a clean, chemically compatible, tightly sealed glass container with a clear label. Handle the material inside a fume hood using safety glasses, chemical-resistant gloves, and a laboratory coat, and avoid inhalation of dust or vapour and contact with skin and eyes. Aromatic amines should be treated as hazardous, so minimise open handling time, keep the working area clean, and collect any residues as halogenated organic chemical waste in accordance with laboratory procedures. Consult the manufacturer's safety data sheet before first use.
Sold out
