TCI
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Description
6-Chloro-2-methylquinoline from TCI, supplied under catalogue code C3108, is a heterocyclic compound of the quinoline family bearing a chlorine substituent at the six position and a methyl group at the two position. The compound serves as a building block — a starting material designed to be elaborated further into more complex target molecules. In organic synthesis laboratories, the quinoline framework is a core structure encountered very frequently in bioactive compounds, dyes, ligands, and functional materials, so having a ready-substituted derivative such as this one saves a considerable number of synthetic steps.
The main appeal of this compound lies in two reactive sites that complement one another. The methyl group at the two position is relatively acidic because it sits adjacent to the ring nitrogen, so it can be deprotonated and reacted through condensation with aldehydes to form conjugated systems such as styryl compounds and cyanine dyes. The chlorine atom on the benzo ring, meanwhile, provides a handle for transition-metal-catalysed cross-coupling reactions or for further downstream modification. Its solid form makes weighing easier to control, and the aromatic structure gives the material the stability expected of a bench-stable intermediate.
In Indonesian laboratories, a substituted quinoline of this kind is typically used in university and institutional research groups working on organic synthesis, medicinal chemistry, and materials chemistry, as well as in industrial R&D units developing dye or ligand chemistry. Because it arrives as a defined, ready-made scaffold, it fits work programmes where reagent availability and step count matter, allowing researchers to move directly to the derivatisation step that is the actual subject of their study.
Laboratory Applications
- Heterocyclic building block synthesis — the pre-installed quinoline core lets researchers begin from a complete scaffold rather than constructing the ring system from simpler precursors themselves.
- Styryl compound preparation — the acidic two-methyl group can be deprotonated and condensed with aldehydes to extend conjugation into larger styryl frameworks efficiently.
- Cyanine dye chemistry — the same methyl condensation route gives access to conjugated dye systems widely studied for their absorption and emission behaviour.
- Transition-metal-catalysed cross-coupling — the chlorine on the benzo ring acts as a reliable handle for coupling reactions that install new carbon or heteroatom substituents.
- Medicinal and materials chemistry exploration — quinoline derivatives recur throughout bioactive compounds, ligands, and functional materials, making this a practical entry point for structure-activity work.
Specifications
- Brand: TCI
- Catalogue code: C3108
- CAS number: 92-46-6
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Physical form: solid
- Pack sizes: available in the pack sizes listed for this catalogue code
Handling and Storage
Store the material in its original tightly closed container, kept in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible chemicals. Because the product is a solid, transfers should be made with a clean, dry spatula onto weighing paper or a weighing boat to avoid introducing moisture or cross-contamination into the bulk container. Handle it inside a fume hood while wearing a laboratory coat, safety glasses, and chemically resistant gloves, following standard laboratory practice for organic intermediates. Reseal the container promptly after use and consult the manufacturer's safety data sheet before first handling and before disposal.
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