TCI D2220 1,2-Dibromo-1-chloro-1,2,2-trifluoroethane is a fluorinated building block that carries three different halogen types at once — bromine, chlorine, and fluorine — on a two-carbon ethane skeleton. Mixed halogenated compounds of this kind play an important role in the laboratory as sources of fluoroalkyl groups, as halogen transfer reagents, and as precursors to fluorinated alkenes through debromination reactions. Because fluorine atoms are difficult to introduce directly into organic molecules, chemists prefer to begin from a material that already carries fluorine at defined positions, and this product answers that need for small-scale research work.
The property that makes it a preferred choice is the reactivity of the carbon–bromine bond, which is far weaker than the carbon–fluorine bond, so bromine can be removed selectively while the fluorination pattern remains intact. The heavy halogen content also makes the compound dense, non-flammable, and relatively inert toward many reagents, a combination that is useful whenever a medium or reagent is required that will not take part in the reaction itself. In addition, the fluorine atoms give a very clear spectroscopic signature in 19F NMR analysis, so the progress of a reaction and the purity of the product can be followed directly.
In Indonesian laboratories, this building block is typically used in university research groups, synthetic chemistry laboratories, and research and development units working on fluorinated intermediates on a small scale. It is generally ordered in research quantities rather than production volumes, supporting method development, exploratory synthesis, and analytical reference work. As a TCI catalogue item, it is normally purchased alongside other fine chemicals for laboratories that require a defined fluorine source for their experimental programmes.
TCI brochures (PDF)
- Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 51
Related TCI products
- Fluorinated intermediate synthesis — supplies a pre-installed fluorine pattern on a two-carbon frame, sparing chemists the difficulty of introducing fluorine atoms directly into an organic molecule.
- Halogen transfer reactions — the weak carbon–bromine bonds allow bromine to be delivered to another substrate while the stronger carbon–fluorine bonds remain untouched throughout the transformation.
- Fluorinated alkene preparation — debromination of this compound removes the two bromine atoms and generates a fluorine-bearing double bond, a common route toward fluorinated olefin targets.
- Inert reaction medium and non-reactive reagent work — its high halogen content makes it dense, non-flammable, and relatively inert, suiting experiments that need a component which does not participate.
- 19F NMR method development and reaction monitoring — the fluorine atoms produce a very distinct spectroscopic signal, letting researchers track reaction progress and assess product purity directly.
| Brand | TCI |
|---|---|
| CAS number | 354-51-8 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | research-scale laboratory quantities; please confirm the available pack size when ordering |
| Physical form | — |
| Storage | store in a closed original container as indicated on the manufacturer's label |
- Chemical name: 1,2-Dibromo-1-chloro-1,2,2-trifluoroethane
- Catalogue code: D2220
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible chemicals such as strong bases and reducing agents. Keep the material in its original manufacturer container, or in a chemically compatible glass container with a secure closure, and ensure the label remains legible at all times. Handle the compound inside a working fume hood and wear standard personal protective equipment, including safety goggles, a laboratory coat, and chemically resistant gloves. Avoid inhaling vapours and prevent contact with skin and eyes. Transfer only the quantity required for the experiment, close the container immediately after use, and dispose of residues and contaminated materials as halogenated chemical waste in accordance with your institution's procedures. Always consult the manufacturer's safety data sheet before first use.
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