Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Couldn't load pickup availability
Description
TCI D4128 2,2-Difluoroethanol is a short-chain aliphatic alcohol carrying two fluorine atoms on the second carbon. The compound is classified as a fluorinated building block, meaning it is a starting material supplied specifically for introducing a difluoromethyl group into the framework of a target molecule. In synthetic laboratories, materials of this type are highly valued because inserting fluorine directly into complex molecules is often difficult and requires harsh reagents, so it is far more practical to begin from a building block whose fluorine substituents are already cleanly installed at the start of the synthetic route.
The presence of two fluorine atoms changes the electronic character of the molecule appreciably: the hydroxyl group becomes more acidic than that of ordinary ethanol, and the strong electron-withdrawing character influences reactivity in substitution, etherification, and esterification reactions. This same property is why the compound is also used as a specialty solvent in certain reactions that demand a polar medium with strong hydrogen-bond-donating ability. As a volatile liquid, handling requires tightly closed containers and prompt dispensing so that the composition does not shift through evaporation during repeated use.
In Indonesian laboratories, this material is typically found in organic synthesis and medicinal chemistry groups at universities and research institutes, as well as in industrial R&D units developing fluorinated intermediates. It is generally used at bench scale for route development and small-batch preparation rather than bulk production, and it is ordered as a catalogue building block from TCI so that researchers can start their synthetic sequence directly from a reliably characterized fluorinated starting material.
Laboratory Applications
Introduction of difluoromethyl groups into target molecules, allowing chemists to build the fluorinated fragment into the skeleton from the beginning instead of relying on harsh late-stage fluorination reagents.
Etherification reactions, where the more acidic hydroxyl group compared with ordinary ethanol facilitates deprotonation and formation of difluoroethyl ethers on suitable electrophilic partners.
Esterification chemistry, in which the electron-withdrawing difluoro substitution modifies the reactivity of the alcohol and gives access to difluoroethyl esters for further synthetic elaboration.
Nucleophilic substitution routes, since the strong electron-withdrawing character of the two fluorine atoms alters reactivity patterns and lets chemists tune the outcome of substitution steps.
Use as a specialty reaction solvent for transformations that require a polar medium with strong hydrogen-bond-donating ability, a role ordinary alcohols cannot fill as effectively.
Specifications
Brand: TCI
CAS Number: 359-13-7
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Product Code: D4128
Physical Form: Volatile liquid
Storage: Keep in a tightly closed container to prevent loss by evaporation
Handling and Storage
Because 2,2-Difluoroethanol is a volatile liquid, it must be kept in tightly closed containers at all times, and the closure should be checked before returning the bottle to storage. Dispensing should be carried out promptly so that the composition of the remaining material does not change through evaporation over repeated use. Handle the material in a well-ventilated area or fume hood, using appropriate personal protective equipment in line with standard laboratory practice for volatile organic chemicals. Store away from incompatible materials and heat sources, and always consult the manufacturer's safety data sheet before use.
