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Description
TCI D3662 (+)-cis-Diltiazem Hydrochloride is a pharmaceutical research reagent belonging to the benzothiazepine class, widely recognised as an L-type calcium channel blocker. The compound is supplied as the hydrochloride salt, a form that makes it easier to weigh, dissolve, and handle at laboratory scale. On the researcher's bench, this material serves as a test substance and reference compound for studying calcium ion transport mechanisms, vascular smooth muscle responses, and the behaviour of cardiac tissue in experimental models. Because its stereochemical identity is clearly defined — the cis isomer with the (+) configuration — the reagent is important for studies that require certainty about the pharmacologically active form rather than an isomer mixture whose results are difficult to interpret.
The characteristics that lead researchers to select this material are its clearly defined stereochemistry and the lot-to-lot quality consistency that distinguishes research-grade reagents. The hydrochloride salt form is generally a crystalline solid that remains stable under reasonable storage conditions, is readily prepared into aqueous stock solutions or solutions in polar solvents, and is well suited to serial dilution for dose-response testing. The specific CAS number simplifies literature searching, method development, and documentation, so that experimental records can be traced back to published work without ambiguity about compound identity.
In Indonesian laboratories, this reagent is typically used in university pharmacology and biochemistry research settings, in pharmaceutical research units, and in teaching laboratories where mechanistic studies of calcium channel function are carried out. It is normally handled by trained personnel following institutional procedures for research chemicals, prepared as stock solutions for downstream assays, and reserved strictly for experimental use rather than any clinical, diagnostic, or therapeutic application.
Laboratory Applications
- Calcium channel mechanism studies — as a defined L-type channel blocker, it provides a pharmacologically characterised tool for probing calcium ion transport pathways in experimental preparations.
- Vascular smooth muscle response experiments — the compound is used as a test substance to examine how smooth muscle tissue responds to calcium channel inhibition under controlled laboratory conditions.
- Cardiac tissue behaviour models — researchers apply it in experimental cardiac models where a well-defined benzothiazepine calcium channel blocker is required for interpreting tissue responses.
- Reference and comparison compound work — its clearly stated stereochemistry and specific CAS number make it suitable as a comparator against which other test compounds are evaluated.
- Dose-response assay development — the hydrochloride salt dissolves readily in aqueous and polar solvents, making it convenient for preparing stock solutions and serial dilutions.
Specifications
- Brand: TCI
- CAS number: 33286-22-5
- Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
- Pack sizes: available in the manufacturer's standard research-scale packaging options
- Physical form: hydrochloride salt, generally a crystalline solid
- Storage: stable under reasonable storage conditions; follow the manufacturer's stated storage recommendations
Handling and Storage
Store the reagent in its original tightly closed container, kept in a cool, dry place away from moisture, direct sunlight, and sources of heat, and follow the storage conditions stated by the manufacturer on the product label. Use clean, dry glass or chemically compatible containers for stock solutions, and label them with the compound name, CAS number, concentration, solvent, and preparation date. Handle the powder in a well-ventilated area or fume hood to avoid inhaling dust, and wear a laboratory coat, gloves, and safety glasses. Weigh and transfer with dedicated clean spatulas to prevent cross-contamination. This material is intended for experimental laboratory use only and should be handled by trained personnel in accordance with institutional safety procedures and the manufacturer's safety data sheet.
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