10-Deacetylbaccatin III TCI D4148

Name: TCI D4148 32981-86-5 10-Deacetylbaccatin III
Brand: TCI
SKU: TCI2510D414824655
Price: 2038050.0 IDR
Availability: InStock

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Berat 100mg 500mg

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Description

TCI D4148 10-Deacetylbaccatin III is a natural product belonging to the taxane class of diterpenoids, obtained naturally from plants of the genus *Taxus*, commonly known as the yew tree. The compound is widely recognized as the core scaffold that serves as the starting point for taxane chemistry, one of the most important classes of molecules in the history of modern drug discovery. In the laboratory, this material is used primarily as a semi-synthetic precursor, an analytical reference standard, and a subject of study in natural product research. Its availability in isolated form saves researchers the long extraction and purification stages that would otherwise be required.

The characteristic that makes this compound valuable is its polycyclic taxane skeleton, which carries an arrangement of hydroxyl and ester groups already established in the correct stereochemical configuration. Such an intricate structure is almost impossible to construct efficiently through total synthesis, so its use as a semi-synthetic starting material offers a substantial advantage. The hydroxyl groups differ in their degree of reactivity, which allows selective modification through stepwise protection, acylation, and side-chain coupling. Researchers can therefore generate a range of taxane analogues in order to study structure-activity relationships.

In Indonesian laboratories, this material is typically handled in university research groups, natural product chemistry laboratories, pharmaceutical development units, and analytical service laboratories. It supports work in which a well-defined taxane scaffold is required either as a synthetic building block or as a comparison standard for identification and method development. Because the isolated compound removes the need for in-house extraction from plant material, it allows research teams to focus their resources directly on synthesis, characterization, and analytical work.

Laboratory Applications

Semi-synthetic precursor work: the pre-formed taxane skeleton with its established stereochemistry lets chemists build taxane derivatives without attempting the impractical route of total synthesis.
Analytical reference standard: a defined, isolated taxane compound provides a reliable comparison point for identification, peak confirmation, and analytical method development in chromatographic and spectroscopic work.
Natural product chemistry research: as a characteristic constituent of *Taxus* species, the compound serves as a study object for investigating taxane biosynthesis, isolation strategies, and natural product structure.
Structure-activity relationship studies: the differing reactivity of its hydroxyl groups permits selective protection, acylation, and side-chain attachment, enabling the preparation of taxane analogue series for comparison.
Selective derivatization and protecting-group methodology: the multiple hydroxyl functions on a complex scaffold make this material a practical substrate for developing and validating stepwise protection and acylation procedures.

Specifications

Brand: TCI
CAS number: 32981-86-5
Category: Life Science > Biochemicals and Reagents > Antibiotics
Product code: D4148
Pack sizes: available in standard research and laboratory pack sizes as offered by the manufacturer
Storage: store according to the conditions stated on the manufacturer label and product documentation

Handling and Storage

Store the container in a cool, dry place, protected from light and moisture, and follow the storage conditions stated on the manufacturer label and accompanying documentation. Keep the material in its original tightly closed container, or in a suitable amber glass or chemically resistant vessel that is clearly labelled with the compound name and product code. Handle the compound in a well-ventilated area or fume hood, and wear appropriate personal protective equipment including gloves, safety glasses, and a laboratory coat. Avoid the generation of dust, avoid contact with skin and eyes, and use clean, dry spatulas and glassware when weighing to prevent contamination. Return the container promptly to its designated storage location after use, and consult the safety data sheet before opening, handling, or disposing of the material.