Docetaxel TCI D4102

Chemical Identity

Other names: N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
CAS No.: 114977-28-5
Formula: C43H53NO14
Molecular weight: 807.89 g/mol
Purity: >98.0%(HPLC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
InChIKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
MDL: MDL00800737
PubChem: CID 148124

Rp 2.942.100,00

Sale Sold out

Shipping calculated at checkout.

Berat 100mg 1g

Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.

Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)

CoA (Certificate of Analysis)

Spesifik per batch produksi — diterbitkan dan dikirim bersama barang sesuai nomor lot yang Anda terima.

Contoh CoA segera tersedia.

💬 Minta CoA via WhatsApp

View full details

TCI D4102 Docetaxel, CAS 114977-28-5, is a taxane-class compound widely recognised as an antimitotic agent. In research laboratories, docetaxel serves as a reference compound and pharmacological tool for studying microtubule dynamics, the cell cycle, and the mechanisms of programmed cell death. The material stabilises microtubules and inhibits their normal depolymerisation, causing cells to arrest at a particular stage of division. Because of its strong and well-defined biological effect, this compound is frequently employed as a positive control in cytotoxicity assays and in the screening of new candidate anticancer compounds.

The properties that make docetaxel a preferred choice are its high potency at low concentrations and its specific mechanism of action on microtubules, which makes experimental results easier to interpret than those obtained with compounds acting on multiple targets. This material is supplied as a solid and is generally dissolved in an organic solvent such as dimethyl sulfoxide to prepare a stock solution, which is then diluted into culture medium. Its limited solubility in water requires careful attention during solution preparation so that precipitation does not occur.

In Indonesian laboratories, this compound is typically used in academic research units, pharmacology and biomedical laboratories, and cell culture facilities working on anticancer screening. It is normally handled in small quantities from a concentrated stock solution, with dilution steps carried out immediately before an assay. As a cytotoxic compound, docetaxel is handled under controlled conditions, with work planned so that exposure is kept to a minimum and the material remains confined to a designated working area.

Microtubule dynamics studies — the compound stabilises microtubules and blocks normal depolymerisation, giving researchers a reliable and reproducible way to perturb the cytoskeleton.
Cell cycle analysis — because it arrests dividing cells at a defined stage, it provides a clear and consistent reference point when examining progression through the cell cycle.
Apoptosis and programmed cell death research — its strong, well-characterised biological effect makes it suitable for investigating the mechanisms that lead cells toward programmed death.
Positive control in cytotoxicity assays — its potency at low concentrations and well-defined response make it a dependable benchmark against which test samples can be compared.
Screening of new anticancer candidate compounds — its specific action on microtubules rather than multiple targets allows results from screening campaigns to be interpreted with greater confidence.

Brand	TCI
CAS number	114977-28-5
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Antibiotics
Pack sizes	—
Physical form	solid; generally dissolved in an organic solvent such as dimethyl sulfoxide to prepare stock solutions
Storage	store according to the conditions stated on the manufacturer's label and accompanying documentation

Catalogue number: D4102

Store the container closed and stored in accordance with the conditions indicated on the manufacturer's label and product documentation. Keep the solid in its original tightly sealed container, protected from moisture, and use containers compatible with organic solvents when preparing and holding stock solutions. Because docetaxel is a cytotoxic compound, handle it with appropriate personal protective equipment, including gloves, a laboratory coat, and eye protection, and carry out weighing and solution preparation in a suitable containment enclosure. Prepare dilutions carefully to avoid precipitation given its limited solubility in water, label all stock solutions clearly, and dispose of residues and contaminated consumables through the laboratory's designated route for cytotoxic waste.

—